| 项目编号 |
PRJCA040062 |
| 项目标题 |
Extensive ancestral gene flow and complex evolutionary dynamics among eastern Tibetan Plateau populations |
| 涉及领域 |
Medical |
| 数据类型 |
Whole genome sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
The origins of Tibeto-Burman populations inhabiting the eastern Tibetan Plateau (TP), particularly within the Tibetan-Yi Corridor, remain elusive. To reconstruct the regional complex peopling history, we performed whole-genome sequencing of 293 individuals from 21 Tibeto-Burman-speaking populations and genotyped 799 individuals from 60 Sino-Tibetan-speaking populations. Our analyses reveal fine-scale population substructure and extensive admixture along the underrepresented Tibetan-Yi and Hexi corridors, driven by substantial gene flow from Eastern Eurasian rice/millet farmers and Western Eurasian steppe pastoralists. We estimate that Tibetans diverged from their common ancestors with Han Chinese during the early Neolithic (~9.9 kya), followed by a middle Neolithic differentiation within Tibetan-Yi Corridor populations between ~1.2 and ~4.6 kya. These divergence events coincide with distinct cultural trajectories that shaped the north-south genetic structure of Tibeto-Burman groups. QpAdm modeling shows that northern Tibeto-Burman-speaking populations derive most of their ancestry from Neolithic millet farmers. Fine-scale analyses along the Hexi Corridor, an essential axis of Eurasian connectivity, reveal a dominant legacy from millet-farming populations, supplemented by contributions from local Eurasian herders. Collectively, these findings illuminate the settlement history of eastern TP populations and highlight the role of geographic and cultural corridors in structuring ancient intercontinental gene flow across Eurasia. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2025-12-03 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41243841
|
Human Population Genetic History and Evolutionary Dynamics on the Eastern Tibetan Plateau
|
Molecular Biology and Evolution
|
10.1093/molbev/msaf258
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82402203
|
|
|
|
| 提交者 |
Guanglin
He (Guanglinhescu@163.com)
|
| 提交单位 |
Institute of Rare Diseases, West China Hospital of Sichuan University |
| 提交日期 |
2025-05-12 |
