| Accession |
PRJCA040062 |
| Title |
Extensive ancestral gene flow and complex evolutionary dynamics among eastern Tibetan Plateau populations |
| Relevance |
Medical |
| Data types |
Whole genome sequencing
|
| Organisms |
Homo sapiens
|
| Description |
The origins of Tibeto-Burman populations inhabiting the eastern Tibetan Plateau (TP), particularly within the Tibetan-Yi Corridor, remain elusive. To reconstruct the regional complex peopling history, we performed whole-genome sequencing of 293 individuals from 21 Tibeto-Burman-speaking populations and genotyped 799 individuals from 60 Sino-Tibetan-speaking populations. Our analyses reveal fine-scale population substructure and extensive admixture along the underrepresented Tibetan-Yi and Hexi corridors, driven by substantial gene flow from Eastern Eurasian rice/millet farmers and Western Eurasian steppe pastoralists. We estimate that Tibetans diverged from their common ancestors with Han Chinese during the early Neolithic (~9.9 kya), followed by a middle Neolithic differentiation within Tibetan-Yi Corridor populations between ~1.2 and ~4.6 kya. These divergence events coincide with distinct cultural trajectories that shaped the north-south genetic structure of Tibeto-Burman groups. QpAdm modeling shows that northern Tibeto-Burman-speaking populations derive most of their ancestry from Neolithic millet farmers. Fine-scale analyses along the Hexi Corridor, an essential axis of Eurasian connectivity, reveal a dominant legacy from millet-farming populations, supplemented by contributions from local Eurasian herders. Collectively, these findings illuminate the settlement history of eastern TP populations and highlight the role of geographic and cultural corridors in structuring ancient intercontinental gene flow across Eurasia. |
| Sample scope |
Monoisolate |
| Release date |
2025-12-03 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 41243841
|
Human Population Genetic History and Evolutionary Dynamics on the Eastern Tibetan Plateau
|
Molecular Biology and Evolution
|
10.1093/molbev/msaf258
|
2025
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
82402203
|
|
|
|
| Submitter |
Guanglin
He (Guanglinhescu@163.com)
|
| Organization |
Institute of Rare Diseases, West China Hospital of Sichuan University |
| Submission date |
2025-05-12 |
