| 项目编号 |
PRJCA040788 |
| 项目标题 |
Vitamin C plus sulfamethoxazole induces bacterial cuproptosis |
| 涉及领域 |
antibiotic |
| 数据类型 |
Metabonomics
|
| 物种名称 |
Escherichia coli
|
| 描述信息 |
Antimicrobial-resistant bacteria pose an urgent threat to human health, and the development of new antimicrobial agents is not keeping pace with the emergence of these bacteria. Therefore, exploring combination therapies of existing antimicrobial agents is one of the best solutions to tackle drug-resistant bacterial infections. To obtain a substitute for trimethoprim in the long-term used combination co-trimoxazole, we found that vitamin C could synergize with sulfamethoxazole at the minimum inhibitory concentration (MIC) level and reverse co-trimoxazole resistance in clinical isolates. Notably, a synergistic bactericidal effect was also observed between vitamin C and sulfamethoxazole in vitro and in vivo, which was independent of the synergistic effect at the MIC level. Similar synergistic effects also existed between vitamin C and trimethoprim or existing antimicrobial drugs targeting bacterial protein synthesis. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2025-10-05 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Vitamin C enhances the bactericidal effect of sulfamethoxazole against Escherichia coli through inducing cuproptosis-like death
|
Microbiological Research
|
10.1016/j.micres.2025.128323
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Major Project of Guangzhou National Laboratory
|
|
GZNL2024A01024
|
|
|
|
| 提交者 |
Mi
Wen (2586890379@qq.com)
|
| 提交单位 |
Wuhan Institute of Virology, Chinese Academy of Sciences |
| 提交日期 |
2025-05-28 |
