| 项目编号 |
PRJCA040844 |
| 项目标题 |
The effect of PERK deficiency on the metabolism of MDA-MB-231/LM2-CTC cells |
| 涉及领域 |
Medical |
| 数据类型 |
Metabonomics
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
This study aims to investigate the regulatory role of protein kinase R-like endoplasmic reticulum kinase (PERK) deficiency in metabolic reprogramming of breast cancer MDA-MB-231/LM2-CTC cells. By performing targeted metabolomics detection and isotope tracing technology on isogenic Scramble control group cells and PERK knockout cells, we will comprehensively analyze the endogenous metabolite profiles and dynamic changes in key metabolic pathways. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2025-10-27 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41212905
|
Unfolded protein response kinase PERK supports survival and metastasis of circulating tumor cell clusters via SAM synthesis and H3K4me3-dependent PDGFB signaling
|
Cancer Communications
|
10.1002/cac2.70072
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82072938
|
|
| The Senior Medical Talents Program of Chongqing Medical University for Young and Middle-aged Scientist
|
|
2021-W0068
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82173155
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82372823
|
|
| The Outstanding Professorship Program of Chongqing Medical University
|
|
R10005
|
|
| The Outstanding Postgraduate Fund of Chongqing Medical University
|
|
BJRC202313
|
|
|
|
| 提交者 |
Rui
Tang (775174072@qq.com)
|
| 提交单位 |
Chongqing Medical University |
| 提交日期 |
2025-05-29 |
