项目编号

PRJCA040945

项目标题

Identification and predictive machine learning models construction of gut microbiota associated with lymph node metastasis in colorectal cancer

涉及领域

Medical

数据类型

Whole genome sequencing

物种名称

human gut metagenome

描述信息

This study focuses on the significant role between gut microbiota and lymph node metastasis (LNM) in colorectal cancer (CRC). By conducting 16S rRNA sequencing on fecal samples from 147 CRC patients and combining it with the linear discriminant analysis effect size algorithm, we successfully identified significant differences in the gut microbiota between patients with LNM and those with no lymph node metastasis (NLNM). This study reveals that Bacteroides plebeius may play an important role in the progression of CRC, with its mechanism potentially involving changes in immune modulation and metabolic pathways. The classification model constructed based on gut microbiota characteristics can predict LNM status of CRC, providing a new perspective for personalized and precision treatment of CRC patients.

样品范围

Environment

发布日期

2025-06-03

出版信息

PubMed ID	文章标题	杂志名称	Doi	发表年份
40626716	Identification and predictive machine learning models construction of gut microbiota associated with lymph node metastasis in colorectal cancer	mSystems	10.1128/msystems.00339-25	2025

项目资金来源

机构	项目类型	授权项目ID	授权项目名称
Natural Science Foundation of Guangxi Province (Guangxi Natural Science Foundation)		2021GXNSFAA196008
Youth Science Foundation of Guangxi Medical University		GXMUYSF202402
Youth Research Project of Guangxi Medical University Affiliated Cancer Hospital		yuanqingji2023-10hao
Middle-aged and Young Teachers' Basic Ability Promotion Project of Guangxi (Basic Ability Promotion Project of Guangxi)		2021KY0087
China Postdoctoral Science Foundation		2023MD734155
Youth Science Foundation of Guangxi Medical University		GXMUYSF202357
Guangxi Key Laboratory of Basic and Translational Research for Colorectal Cancer		-

提交者

Weizhong Tang (tangweizhong@gxmu.edu.cn)

提交单位

Guangxi Medical University Cancer Hospital

提交日期

2025-05-31

项目包含数据信息

资源名称	描述
BioSample (147) show	-
SAMC5203786	16sRNA sequencing of colorectal cancer patient: stoolS0239
SAMC5203785	16sRNA sequencing of colorectal cancer patient: stoolM0240
SAMC5203784	16sRNA sequencing of colorectal cancer patient: stoolF293
SAMC5203783	16sRNA sequencing of colorectal cancer patient: stoolF290
SAMC5203782	16sRNA sequencing of colorectal cancer patient: stoolF289
SAMC5203781	16sRNA sequencing of colorectal cancer patient: stoolF287
SAMC5203780	16sRNA sequencing of colorectal cancer patient: stoolF285
SAMC5203779	16sRNA sequencing of colorectal cancer patient: stoolF283
SAMC5203778	16sRNA sequencing of colorectal cancer patient: stoolF281
SAMC5203777	16sRNA sequencing of colorectal cancer patient: stoolF280
SAMC5203776	16sRNA sequencing of colorectal cancer patient: stoolF277
SAMC5203775	16sRNA sequencing of colorectal cancer patient: stoolF272
SAMC5203774	16sRNA sequencing of colorectal cancer patient: stoolF271
SAMC5203773	16sRNA sequencing of colorectal cancer patient: stoolF270
SAMC5203772	16sRNA sequencing of colorectal cancer patient: stoolF269
SAMC5203771	16sRNA sequencing of colorectal cancer patient: stoolF265
SAMC5203770	16sRNA sequencing of colorectal cancer patient: stoolF262
SAMC5203769	16sRNA sequencing of colorectal cancer patient: stoolF261
SAMC5203768	16sRNA sequencing of colorectal cancer patient: stoolF260
SAMC5203767	16sRNA sequencing of colorectal cancer patient: stoolF259
SAMC5203766	16sRNA sequencing of colorectal cancer patient: stoolF256
SAMC5203765	16sRNA sequencing of colorectal cancer patient: stoolF255
SAMC5203764	16sRNA sequencing of colorectal cancer patient: stoolF254
SAMC5203763	16sRNA sequencing of colorectal cancer patient: stoolF249
SAMC5203762	16sRNA sequencing of colorectal cancer patient: stoolF248
SAMC5203761	16sRNA sequencing of colorectal cancer patient: stoolF244
SAMC5203760	16sRNA sequencing of colorectal cancer patient: stoolF243
SAMC5203759	16sRNA sequencing of colorectal cancer patient: stoolF240
SAMC5203758	16sRNA sequencing of colorectal cancer patient: stoolF234
SAMC5203757	16sRNA sequencing of colorectal cancer patient: stoolF233
SAMC5203756	16sRNA sequencing of colorectal cancer patient: stoolF232
SAMC5203755	16sRNA sequencing of colorectal cancer patient: stoolF231
SAMC5203754	16sRNA sequencing of colorectal cancer patient: stoolF230
SAMC5203753	16sRNA sequencing of colorectal cancer patient: stoolF227
SAMC5203752	16sRNA sequencing of colorectal cancer patient: stoolF224
SAMC5203751	16sRNA sequencing of colorectal cancer patient: stoolF223
SAMC5203750	16sRNA sequencing of colorectal cancer patient: stoolF221
SAMC5203749	16sRNA sequencing of colorectal cancer patient: stoolF220
SAMC5203748	16sRNA sequencing of colorectal cancer patient: stoolF219
SAMC5203747	16sRNA sequencing of colorectal cancer patient: stoolF217
SAMC5203746	16sRNA sequencing of colorectal cancer patient: stoolF215
SAMC5203745	16sRNA sequencing of colorectal cancer patient: stoolF214
SAMC5203744	16sRNA sequencing of colorectal cancer patient: stoolF213
SAMC5203743	16sRNA sequencing of colorectal cancer patient: stoolF212
SAMC5203742	16sRNA sequencing of colorectal cancer patient: stoolF211
SAMC5203741	16sRNA sequencing of colorectal cancer patient: stoolF210
SAMC5203740	16sRNA sequencing of colorectal cancer patient: stoolF208
SAMC5203739	16sRNA sequencing of colorectal cancer patient: stoolF205
SAMC5203738	16sRNA sequencing of colorectal cancer patient: stoolF204
SAMC5203737	16sRNA sequencing of colorectal cancer patient: stoolF203
SAMC5203736	16sRNA sequencing of colorectal cancer patient: stoolF200
SAMC5203735	16sRNA sequencing of colorectal cancer patient: stoolF199
SAMC5203734	16sRNA sequencing of colorectal cancer patient: stoolF198
SAMC5203733	16sRNA sequencing of colorectal cancer patient: stoolF197
SAMC5203732	16sRNA sequencing of colorectal cancer patient: stoolF196
SAMC5203731	16sRNA sequencing of colorectal cancer patient: stoolF194
SAMC5203730	16sRNA sequencing of colorectal cancer patient: stoolF188
SAMC5203729	16sRNA sequencing of colorectal cancer patient: stoolF187
SAMC5203728	16sRNA sequencing of colorectal cancer patient: stoolF186
SAMC5203727	16sRNA sequencing of colorectal cancer patient: stoolF185
SAMC5203726	16sRNA sequencing of colorectal cancer patient: stoolF184
SAMC5203725	16sRNA sequencing of colorectal cancer patient: stoolF183
SAMC5203724	16sRNA sequencing of colorectal cancer patient: stoolF182
SAMC5203723	16sRNA sequencing of colorectal cancer patient: stoolF181
SAMC5203722	16sRNA sequencing of colorectal cancer patient: stoolF178
SAMC5203721	16sRNA sequencing of colorectal cancer patient: stoolF174
SAMC5203720	16sRNA sequencing of colorectal cancer patient: stoolF172
SAMC5203719	16sRNA sequencing of colorectal cancer patient: stoolF171
SAMC5203718	16sRNA sequencing of colorectal cancer patient: stoolF170
SAMC5203717	16sRNA sequencing of colorectal cancer patient: stoolF168
SAMC5203716	16sRNA sequencing of colorectal cancer patient: stoolF167
SAMC5203715	16sRNA sequencing of colorectal cancer patient: stoolF164
SAMC5203714	16sRNA sequencing of colorectal cancer patient: stoolF162
SAMC5203713	16sRNA sequencing of colorectal cancer patient: stoolF161
SAMC5203712	16sRNA sequencing of colorectal cancer patient: stoolF160
SAMC5203711	16sRNA sequencing of colorectal cancer patient: stoolF159
SAMC5203710	16sRNA sequencing of colorectal cancer patient: stoolF156
SAMC5203709	16sRNA sequencing of colorectal cancer patient: stoolF152
SAMC5203708	16sRNA sequencing of colorectal cancer patient: stoolF150
SAMC5203707	16sRNA sequencing of colorectal cancer patient: stoolF148
SAMC5203706	16sRNA sequencing of colorectal cancer patient: stoolF146
SAMC5203705	16sRNA sequencing of colorectal cancer patient: stoolF145
SAMC5203704	16sRNA sequencing of colorectal cancer patient: stoolF142
SAMC5203703	16sRNA sequencing of colorectal cancer patient: stoolF140
SAMC5203702	16sRNA sequencing of colorectal cancer patient: stoolF138
SAMC5203701	16sRNA sequencing of colorectal cancer patient: stoolF136
SAMC5203700	16sRNA sequencing of colorectal cancer patient: stoolF135
SAMC5203699	16sRNA sequencing of colorectal cancer patient: stoolF134
SAMC5203698	16sRNA sequencing of colorectal cancer patient: stoolF133
SAMC5203697	16sRNA sequencing of colorectal cancer patient: stoolF132
SAMC5203696	16sRNA sequencing of colorectal cancer patient: stoolF131
SAMC5203695	16sRNA sequencing of colorectal cancer patient: stoolF130
SAMC5203694	16sRNA sequencing of colorectal cancer patient: stoolF129
SAMC5203693	16sRNA sequencing of colorectal cancer patient: stoolF126
SAMC5203692	16sRNA sequencing of colorectal cancer patient: stoolF125
SAMC5203691	16sRNA sequencing of colorectal cancer patient: stoolF124
SAMC5203690	16sRNA sequencing of colorectal cancer patient: stoolF122
SAMC5203689	16sRNA sequencing of colorectal cancer patient: stoolF120
SAMC5203688	16sRNA sequencing of colorectal cancer patient: stoolF119
SAMC5203687	16sRNA sequencing of colorectal cancer patient: stoolF118
SAMC5203686	16sRNA sequencing of colorectal cancer patient: stoolF115
SAMC5203685	16sRNA sequencing of colorectal cancer patient: stoolF113
SAMC5203684	16sRNA sequencing of colorectal cancer patient: stoolF110
SAMC5203683	16sRNA sequencing of colorectal cancer patient: stoolF109
SAMC5203682	16sRNA sequencing of colorectal cancer patient: stoolF108
SAMC5203681	16sRNA sequencing of colorectal cancer patient: stoolF107
SAMC5203680	16sRNA sequencing of colorectal cancer patient: stoolF106
SAMC5203679	16sRNA sequencing of colorectal cancer patient: stoolF104
SAMC5203678	16sRNA sequencing of colorectal cancer patient: stoolF102
SAMC5203677	16sRNA sequencing of colorectal cancer patient: stoolF100
SAMC5203676	16sRNA sequencing of colorectal cancer patient: stoolF099
SAMC5203675	16sRNA sequencing of colorectal cancer patient: stoolF098
SAMC5203674	16sRNA sequencing of colorectal cancer patient: stoolF096
SAMC5203673	16sRNA sequencing of colorectal cancer patient: stoolF095
SAMC5203672	16sRNA sequencing of colorectal cancer patient: stoolF093
SAMC5203671	16sRNA sequencing of colorectal cancer patient: stoolF091
SAMC5203670	16sRNA sequencing of colorectal cancer patient: stoolF089
SAMC5203669	16sRNA sequencing of colorectal cancer patient: stoolF084
SAMC5203668	16sRNA sequencing of colorectal cancer patient: stoolF083
SAMC5203667	16sRNA sequencing of colorectal cancer patient: stoolF082
SAMC5203666	16sRNA sequencing of colorectal cancer patient: stoolF081
SAMC5203665	16sRNA sequencing of colorectal cancer patient: stoolF080
SAMC5203664	16sRNA sequencing of colorectal cancer patient: stoolF079
SAMC5203663	16sRNA sequencing of colorectal cancer patient: stoolF078
SAMC5203662	16sRNA sequencing of colorectal cancer patient: stoolF076
SAMC5203661	16sRNA sequencing of colorectal cancer patient: stoolF072
SAMC5203660	16sRNA sequencing of colorectal cancer patient: stoolF071
SAMC5203659	16sRNA sequencing of colorectal cancer patient: stoolF070
SAMC5203658	16sRNA sequencing of colorectal cancer patient: stoolF069
SAMC5203657	16sRNA sequencing of colorectal cancer patient: stoolF068
SAMC5203656	16sRNA sequencing of colorectal cancer patient: stoolF067
SAMC5203655	16sRNA sequencing of colorectal cancer patient: stoolF066
SAMC5203654	16sRNA sequencing of colorectal cancer patient: stoolF063
SAMC5203653	16sRNA sequencing of colorectal cancer patient: stoolF061
SAMC5203652	16sRNA sequencing of colorectal cancer patient: stoolF060
SAMC5203651	16sRNA sequencing of colorectal cancer patient: stoolF059
SAMC5203650	16sRNA sequencing of colorectal cancer patient: stoolF058
SAMC5203649	16sRNA sequencing of colorectal cancer patient: stoolF057
SAMC5203648	16sRNA sequencing of colorectal cancer patient: stoolF056
SAMC5203647	16sRNA sequencing of colorectal cancer patient: stoolF055
SAMC5203646	16sRNA sequencing of colorectal cancer patient: stoolF052
SAMC5203645	16sRNA sequencing of colorectal cancer patient: stoolF051
SAMC5203644	16sRNA sequencing of colorectal cancer patient: stoolF050
SAMC5203643	16sRNA sequencing of colorectal cancer patient: stoolF049
SAMC5203642	16sRNA sequencing of colorectal cancer patient: stoolF048
SAMC5203641	16sRNA sequencing of colorectal cancer patient: stoolF047
SAMC5203640	16sRNA sequencing of colorectal cancer patient: stoolF046