| 项目编号 |
PRJCA041056 |
| 项目标题 |
APTM immunomodulation study |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
This study was designed to investigate the potential immunomodulatory properties of a novel pleuromutilin derivative, APTM (14-O-[(4-amino-6-hydroxy-pyrimidine-2-yl) thioacetyl] mutilin), beyond its established antibacterial activity. To explore this, we established an *in vitro* model of inflammation by stimulating the murine macrophage cell line RAW 264.7 with lipopolysaccharide (LPS) and subsequently performed transcriptome-wide analysis using RNA sequencing (RNA-Seq) to profile gene expression changes following APTM treatment. The primary objective of this project is to identify the molecular pathways and key genes regulated by APTM during an inflammatory response. The resulting dataset offers a comprehensive resource for understanding the anti-inflammatory mechanism of APTM, providing a foundation for its potential development as a therapeutic agent with dual antibacterial and anti-inflammatory functions. |
| 样品范围 |
Single cell |
| 发布日期 |
2025-06-03 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| No funding support
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| 提交者 |
Weicong
Yang (531145649@qq.com)
|
| 提交单位 |
South China Agricultural University |
| 提交日期 |
2025-06-03 |
