| 项目编号 |
PRJCA041569 |
| 项目标题 |
Genomic pathogenic alterations in the SWI/SNF complex compromise the outcomes of immunotherapy in Chinese patients with KRAS-mutant NSCLC by downregulating STING expression |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Genome sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Investigation of SWI/SNF complex gene mutations in KRAS-mutant non-small cell lung cancer (NSCLC) and their association with immune checkpoint blockade (ICB) response. Includes genomic and transcriptomic (RNA-seq) analyses to identify prognostic markers and potential mechanisms, such as STING pathway modulation. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-06-13 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41340120
|
Genomic pathogenic alterations in the SWI/SNF complex compromise the outcomes of immunotherapy in Chinese patients with KRAS-mutant NSCLC by downregulating STING expression
|
BMC Medicine
|
10.1186/s12916-025-04561-6
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82173202
|
|
| Guangdong Provincial Key Lab of Translational Medicine in Lung Cancer
|
|
2017B030314120
|
|
| Guangdong Provincial Natural Science Program
|
|
2019A1515010900
|
|
| Guangzhou S&T Project
|
|
202102080096
|
|
| Guangzhou S&T City and University United Project
|
|
2023A03J043
|
|
| Guangdong Provincial Natural Science Program
|
|
2022A1515012376
|
|
|
|
| 提交者 |
Xuchao
Zhang (zhxuchao3000@126.com)
|
| 提交单位 |
Guangdong Provincial People's Hospital |
| 提交日期 |
2025-06-13 |
