| 项目编号 |
PRJCA041981 |
| 项目标题 |
Gut microbiota-derived Trimethylamine N-oxide impairs spermatogenesis |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Metabonomics
|
| 物种名称 |
Mus musculus
Bacteria
|
| 描述信息 |
Growing evidence indicates that the gut microbiota plays a crucial role in male reproductive health; however, its impact on spermatogenic dysfunction remains insufficiently explored. This study investigates the role of gut microbiota in male reproductive health, focusing on the choline-to-trimethylamine (TMA) microbe and the microbial metabolite trimethylamine N-oxide (TMAO). Metabolomics, together with in vitro validation, confirmed that Phocaeicola massiliensis, Veillonella sp., and Klebsiella pneumoniae convert choline into TMA. Elevated serum TMAO was negatively associated with sperm quality. Transcriptomic analysis of mouse testis after TMAO intervention revealed activation of Hippo signaling and mitochondrial dysfunction. |
| 样品范围 |
Multispecies |
| 发布日期 |
2025-06-20 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41285255
|
Trimethylamine-N-oxide disrupts spermatogenesis by inducing mitochondrial oxidative stress injury through Hippo signaling
|
Free Radical Biology & Medicine
|
10.1016/j.freeradbiomed.2025.11.052
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
Key Program
|
82130068
|
|
|
|
| 提交者 |
Shuo
Wang (mywanuo@163.com)
|
| 提交单位 |
Southern Medical University, Zhujiang hospital |
| 提交日期 |
2025-06-20 |
