| 项目编号 |
PRJCA042247 |
| 项目标题 |
CD8+ TILs in necrotic tumor areas after neoadjuvant immunotherapy predicts recurrence and survival in non-small-cell lung cancer |
| 涉及领域 |
Medical |
| 数据类型 |
Clinical information
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
This project aims to identify novel prognostic biomarkers for non-small-cell lung cancer (NSCLC) patients who received neoadjuvant immunotherapy. A total of 229 tumor samples were collected from three medical centers, following treatment with PD-1 blockade combined with chemotherapy. The study discovered that CD8+ tumor-infiltrating lymphocytes in necrotic tumor areas (nTILs) are a strong predictor of event-free survival (EFS). CD8+ nTIL density demonstrated superior prognostic value compared to traditional pathological and radiological assessments. This project provides new insights into immune responses after neoadjuvant immunotherapy and offers potential clinical markers to guide treatment decisions in NSCLC. |
| 样品范围 |
Multispecies |
| 发布日期 |
2025-11-04 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41062493
|
CD8 + TILs in necrotic tumors after neoadjuvant immunochemotherapy predict outcomes in non-small-cell lung cancer patients
|
Signal Transduction and Targeted Therapy
|
10.1038/s41392-025-02435-0
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Chinese Academy of Sciences (CAS)
|
Strategic Priority Research Program of Chinese Academy of Sciences (CAS)
|
XDC0200000
|
|
|
|
| 提交者 |
Hezhe
Lu (Hezhe@ioz.ac.cn)
|
| 提交单位 |
Institute of Zoology, Chinese Academy of Sciences (CAS) |
| 提交日期 |
2025-06-26 |
