| 项目编号 |
PRJCA042343 |
| 项目标题 |
Elucidating fetal brain development and neurological disorder evolution |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
This project aims to investigate the molecular and cellular mechanisms underlying congenital neurological disorders during human fetal development, including neural tube defects, cleft lip and palate, Down syndrome, and tetralogy of Fallot. To achieve this, we collect brain tissue samples from clinically indicated aborted fetuses across a range of gestational ages. By applying single-nucleus RNA sequencing (snRNA-seq), we construct high-resolution transcriptional and spatial atlases of the fetal brain. These datasets will allow us to delineate the dynamic changes in cell type composition, gene expression patterns, and spatial organization associated with disease-specific developmental trajectories. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-11-09 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40000609
|
|
|
|
|
| 41381484
|
Mid-gestational cell-type-specific transcriptomic signatures in the prefrontal and superior temporal cortex in Down syndrome
|
Nature Communications
|
10.1038/s41467-025-66109-9
|
2025
|
| 41117157
|
Single‐Nucleus RNA Sequencing Reveals Mid‐Gestational Neurodevelopment Features in the Superior Temporal Plane from Fetuses with Nonsyndromic Cleft Lip and Palate
|
Advanced Science
|
10.1002/advs.202504191
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Guizhou Provincial Science and Technology Department
|
|
YQK-2023-040
|
Guizhou Province Distinguished Young Scientific and Technological Talent Program
|
| Guizhou Provincial Science and Technology Department
|
|
2023-072
|
Guizhou Provincial Higher Education Science and Technological Innovation Team
|
| Zunyi Medical University
|
|
ZYSE-2021-03
|
Zunyi Medical University 12345 Future Talent Training Program-Technology Elite
|
| Chinese Ministry of Education
|
|
2020-39
|
Collaborative Innovation Center of Chinese Ministry of Education
|
|
|
| 提交者 |
Liulin
Xiong (xiongliulin@zmu.edu.cn)
|
| 提交单位 |
Zunyi Medical University |
| 提交日期 |
2025-06-28 |
