| 项目编号 |
PRJCA042930 |
| 项目标题 |
L1HS elements reprogrammed microenvironment |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Pathogenic LINE-1 (pL1HS) retrotransposons promote LUSC progression by fostering immune evasion, but the mechanistic link between retrotransposon activity and TIME suppression remains unclear. We found that pL1HS drives immune suppression via liquid-liquid phase separation (LLPS)-mediated DNA sensing. Integrating multi-omics analyses-including bulk and single-cell RNA-seq with spatial proteomics-we reveal that pL1HS+ LUSC exhibits hyperactivated cGAS-STING signaling and a myeloid-derived suppressor cells (MDSCs)-rich TIME. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2025-07-10 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82173198
|
|
|
|
| 提交者 |
Jinpu
Yu (jyu@tmu.edu.cn)
|
| 提交单位 |
Tianjin Medical University Cancer Institute and Hospital |
| 提交日期 |
2025-07-10 |
