| 项目编号 | PRJCA043238 | |||||||||||||||
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| 项目标题 | Multi-omics analysis reveals the molecular mechanisms of gut microbiota in Parkinson's disease | |||||||||||||||
| 涉及领域 | Medical | |||||||||||||||
| 数据类型 |
Metagenome
Single cell sequencing Metabonomics |
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| 物种名称 |
mouse gut metagenome
Mus musculus |
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| 描述信息 | PD is the second most common neurodegenerative disorder, marked by motor and GI symptoms. Gut microbiota dysbiosis is closely involved in PD pathogenesis. Our study shows that PD patient-derived microbiota induces PD-like symptoms in the GF mice. By leveraging a multi-omics approach including midbrain snRNA-seq, fecal metagenomics, and serum metabolomics, it suggests that gut microbiota dysbiosis may drive the metabolic alterations that compromise BBB integrity, ultimately promoting dopaminergic neurodegeneration. Notably, microbiota-derived bile acid DCA emerges as a critical contributor to disease progression. | |||||||||||||||
| 样品范围 | Multispecies | |||||||||||||||
| 发布日期 | 2025-07-31 | |||||||||||||||
| 出版信息 |
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| 项目资金来源 |
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| 提交者 | Zhe Zhao (zhaoz2017@sina.com) | |||||||||||||||
| 提交单位 | Peking University Third Hospital | |||||||||||||||
| 提交日期 | 2025-07-15 |