项目编号

PRJCA043342

项目标题

A macromolecular JAK inhibitor for treating acute inflammation

涉及领域

Medical

数据类型

Transcriptome or Gene expression

物种名称

Mus musculus

描述信息

Uncontrolled and sustained inflammation is inextricably associated with the pathogenesis of numerous diseases. However, there is still demand for effective and safe anti-inflammatory therapies. Here we report a potent anti-inflammatory macromolecular therapy named HPL. Leveraging its amphiphilic nature, HPL can spontaneously self-assemble into micelles capable of targeting inflamed tissues and localizing in inflammatory cells. In mice with acute lung, kidney, and liver injuries, as well as endotoxemia, HPL demonstrates anti-inflammatory effects. HPL exerts its anti-inflammatory activity mainly by inhibiting the IL-6/JAK2/STAT3 signaling pathway.

样品范围

Multiisolate

发布日期

2025-09-26

项目资金来源

机构	项目类型	授权项目ID	授权项目名称
National Natural Science Foundation of China (NSFC)	General Program	32271451

提交者

Min Zhou (minzhou10@163.com)

提交单位

Xinqaio Hospital

提交日期

2025-07-17

项目包含数据信息

资源名称	描述
BioSample (12) show	-
SAMC5649388	RNA-Seq of mus musculus; B16F10 cells treated without Celastrol 9
SAMC5649387	RNA-Seq of mus musculus; B16F10 cells treated without Celastrol 8
SAMC5649386	RNA-Seq of mus musculus; B16F10 cells treated without Celastrol 7
SAMC5649385	RNA-Seq of mus musculus; B16F10 cells treated without Celastrol 6
SAMC5649384	RNA-Seq of mus musculus; B16F10 cells treated without Celastrol 5
SAMC5649383	RNA-Seq of mus musculus; B16F10 cells treated without Celastrol 4
SAMC5649382	RNA-Seq of mus musculus; B16F10 cells treated without Celastrol 3
SAMC5649381	RNA-Seq of mus musculus; B16F10 cells treated without Celastrol 2
SAMC5649380	RNA-Seq of mus musculus; B16F10 cells treated without Celastrol 1
SAMC5649379	RNA-Seq of mus musculus; B16F10 cells treated with Celastrol 3
SAMC5649378	RNA-Seq of mus musculus; B16F10 cells treated with Celastrol 2
SAMC5649377	RNA-Seq of mus musculus; B16F10 cells treated with Celastrol 1
GSA (1)	-
CRA028017	a macromolecular JAK inhibitor for treating acute inflammation