| Accession |
PRJCA043478 |
| Title |
Construction of nanoscale coordination polymer to regulate tumor stem cells for overcoming renal cell carcinoma radioresistance and metastasis |
| Relevance |
Medical |
| Data types |
Metabonomics
|
| Organisms |
Homo sapiens
|
| Description |
Based on gadolinium and GSH/TXN inhibitor NQA, we established a new nanoscale coordination polymer NGd-NCPs to differentiate tumor stem cells, making them sensitive to oxidative stress treatment. Then, the amplified oxidative stress would enhance radio-mediated immunogenic cell death, improve the activation of antigen-presenting cells, and induce a systemic anti-tumor immune response to overcome the advanced stage of renal cell carcinoma. We hope that our research could provide new ideas and directions for the treatment of advanced renal cell carcinoma. |
| Sample scope |
Monoisolate |
| Release date |
2025-09-19 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 41203631
|
SLC6A19-mediated tryptophan uptake suppresses renal cell carcinoma metastasis via activating NAD+-dependent deacetylase SIRT1
|
Oncogenesis
|
10.1038/s41389-025-00580-3
|
2025
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
82172777
|
|
|
|
| Submitter |
Changwei
Ji (jichangwei@nju.edu.cn)
|
| Organization |
Department of Urology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Institute of Urology, Nanjing University |
| Submission date |
2025-07-21 |
