| 项目编号 |
PRJCA044299 |
| 项目标题 |
Unveiling the Landscape of EGFR T790I Mutation in NSCLC: Clinical Implications and Therapeutic Insights |
| 涉及领域 |
Medical |
| 数据类型 |
Genome sequencing
|
| 物种名称 |
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| 描述信息 |
The EGFR T790I mutation has been implicated as a potential resistance mechanism against EGFR tyrosine kinase inhibitors (TKIs) in NSCLC. However, its prevalence and clinical significance remain to be explored. We aim to delineate the mutational spectrum of EGFR T790I in NSCLC patients and to investigate its association with clinical outcomes and resistance to EGFR-targeted therapies. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2026-01-15 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41310499
|
Prevalence and therapeutic response of EGFR T790I mutation in NSCLC patients with acquired resistance to EGFR-TKIs: a retrospective cohort study
|
BMC Cancer
|
10.1186/s12885-025-14885-4
|
2025
|
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| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| No funding support
|
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| 提交者 |
Haiyan
Xie (1246641205@qq.com)
|
| 提交单位 |
Nanjing Chest Hospital,Affiliated Nanjing Brain Hospital,Nanjing Medical University |
| 提交日期 |
2025-08-05 |
