| 项目编号 |
PRJCA044527 |
| 项目标题 |
Metabolome data of cecal contents from mice on a restricted diet |
| 涉及领域 |
Medical |
| 数据类型 |
Metabonomics
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
Time-restricted feeding (TRF) shows promise in affecting body metabolic homeostasis by modulating circadian rhythms, but its effects on male fertility remain largely unexplored. This study aimed to investigate how different TRF patterns influence testicular homeostasis and spermatogenesis, specifically focusing on the role of gut microbiota and its metabolites within the "gut-testis" axis. We compared two groups of mice: those on a daytime-restricted feeding (DRF) schedule and those on a nighttime-restricted feeding (NRF) schedule, against a control group (Ctr) that had ad libitum access to food. We observed a significant reduction in testicular index and sperm quality in the NRF group; no impacts were found in the DRF group. Histological analysis confirmed a decreased number of spermatocytes and spermatozoa in NRF group. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-08-10 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41634190
|
Nighttime-restricted feeding disrupts spermatogenesis in mice via gut microbiota-derived KYNA homeostasis
|
Communications Biology
|
10.1038/s42003-026-09619-6
|
2026
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
32071161
|
|
|
|
| 提交者 |
Donghui
Yang (17792612916@163.com)
|
| 提交单位 |
Sichuan Agricultural University |
| 提交日期 |
2025-08-10 |
