| 项目编号 |
PRJCA045216 |
| 项目标题 |
AAV-Delivered Engineered Suppressor tRNA Rescues Visual Function in Mice with an Inherited Retinal Disease (ribo-seq) |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
At the age of two weeks, subretinal injections were performed on the mice under a stereomicroscope. Each eye of a mouse was injected with 1 μL of scAAV8.sup-tRNA at the dose of 1x109 GC/eye. 12 weeks post injection, the eyes were enucleated and retina/RPE/choroidal/sclera complex were dissociated and immediately frozen in liquid nitrogen and ground to power in liquid nitrogen with a mortar and pestle, then dissolved in 400μL of lysis buffer. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-09-28 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41407712
|
AAV-delivered engineered suppressor tRNA rescues visual function in mice with an inherited retinal disease
|
Nature Communications
|
10.1038/s41467-025-66176-y
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82222030
|
|
| National Natural Science Foundation of China (NSFC)
|
|
U22A20311
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82201212
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82201210
|
|
| National Key R&D Program of China
|
|
2023YFC3403300
|
|
| National Key R&D Program of China
|
|
2023YFC3403302
|
|
| National Key R&D Program of China
|
|
2024YFC3406704
|
|
| Sichuan Science and Technology Program
|
|
2025ZNSFSC1710
|
|
| China Postdoctoral Science Foundation
|
|
2024M762227
|
|
|
|
| 提交者 |
Chengda
Ren (drren@wchscu.cn)
|
| 提交单位 |
West China hospital |
| 提交日期 |
2025-08-25 |
