| 项目编号 |
PRJCA045259 |
| 项目标题 |
Engineered Outer Membrane Vesicles enhance solid tumor CAR-T cell therapy |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
We developed a bacterial OMV-based immunosuppression reversal and optimized antigen decoration platform for CAR-T therapy (BROAD-CAR), in which OMVs were modified to express a high-affinity anti-PD-L1 antibody and load plasmids encoding the target antigen for CARs. By blocking the PD-1/PD-L1 signaling pathway, this tumour-targeting platform enhanced the anti-tumour activity of CAR-T cells both in vitro and in vivo, and boosted CAR-T cell expansion by ameliorating the tumour microenvironment. |
| 样品范围 |
Single cell |
| 发布日期 |
2025-09-02 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China
|
|
82403891
|
|
| National Postdoctoral Program for Innovative Talents (China Postdoctoral Science Foundation)
|
|
BX20240098
|
|
| China Postdoctoral Science Foundation
|
|
2023MD744211
|
|
|
|
| 提交者 |
Tongsen
Zheng (zhengtongsen@hrbmu.edu.cn)
|
| 提交单位 |
Harbin Medical University Cancer Hospital |
| 提交日期 |
2025-08-26 |
