| 项目编号 |
PRJCA045393 |
| 项目标题 |
Septic Cardiomyopathy |
| 涉及领域 |
Medical |
| 数据类型 |
Whole genome sequencing
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
Sepsis is a systemic inflammatory syndrome caused by infection and is a major contributor to multi-organ dysfunction. Cardiac impairment is one of the most critical complications leading to poor outcomes in septic patients. In this study, we established a murine cecal ligation and puncture (CLP) model to induce sepsis and collected heart tissues for long non-coding RNA (lncRNA) transcriptome sequencing. This dataset provides a comprehensive lncRNA expression profile associated with septic cardiomyopathy, which may help to elucidate the underlying molecular mechanisms and identify potential diagnostic biomarkers and therapeutic targets. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2025-09-01 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41073440
|
Cardiomyocyte lncRNA Cpat maintains cardiac homeostasis and mitochondria function by targeting citrate synthase acetylation
|
Nature Communications
|
10.1038/s41467-025-64072-z
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82170242
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81570454
|
|
|
|
| 提交者 |
Fan
Yu (l220133@zju.edu.cn)
|
| 提交单位 |
The Second Affiliated Hospital, Zhejiang University School of Medicine |
| 提交日期 |
2025-08-28 |
