| 项目编号 |
PRJCA045755 |
| 项目标题 |
Single cell RNA sequencing on synovium, meniscus, subchondral bone and cartilage of osteoarthritis |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
As OA is a complex disease involving multiple tissues of the whole joint, we next tried to identify the main tissues and specific cell type responding to denosumab. We harvested cells from the whole joint of sham, DMM and DMM + denosumab groups at 4 weeks after DMM surgery for single-cell RNA sequencing (scRNA-seq), including cartilage, subchondral bone, meniscus, and synovium. |
| 样品范围 |
Single cell |
| 发布日期 |
2025-10-30 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41407913
|
Denosumab attenuates knee osteoarthritis progression by inhibiting synovial inflammation via the RANK/TRAF6/FSTL1 signalling
|
Nature Communications
|
10.1038/s41467-025-66202-z
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82372465
|
|
|
|
| 提交者 |
yuxiang
Hu (d202382057@hust.edu.cn)
|
| 提交单位 |
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology |
| 提交日期 |
2025-09-05 |
