| 项目编号 |
PRJCA046448 |
| 项目标题 |
Efficacy and immunomodulatory effect of Claudin18.2-specific IL-7/XCL1 armored CAR-T cells in digestive tract cancer: Preclinical and clinical analysis |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
|
| 描述信息 |
CAR-T cell therapy has limited efficacy in solid tumors, such as digestive tract cancer (DTC), largely because of the tumor microenvironment (TME) and the limitations of CAR-T cell function. Here, we constructed fourth-generation CLDN18.2-targeted CAR-T cells that concurrently secrete IL-7 and XCL1(ExCAR-T cells, also referred to as RD07 in clinical trial). |
| 样品范围 |
Monoisolate |
| 发布日期 |
2025-09-23 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| The National Key R&D Program: Intergovernmental International Science and Technology Innovation Cooperation Project
|
|
2022YFE0141000
|
|
|
|
| 提交者 |
Zhen
Zhang (zhangzhen05202024@outlook.com)
|
| 提交单位 |
The First Affiliated Hospital of Zhengzhou University |
| 提交日期 |
2025-09-17 |
