1. Home
  2. Browse
  3. PRJCA047782
项目编号 PRJCA047782
项目标题 LBX2 Promotes Colorectal Cancer Progression via the Glycosylation and Lactylation Positive Feedback
涉及领域 Medical
数据类型 Epigenomics
Transcriptome or Gene expression
物种名称 Homo sapiens
描述信息 Colorectal cancer (CRC) ranks as a leading cause of cancer-related mortality worldwide, yet its molecular mechanisms remain incompletely understood. The transcription factor LBX2 regulates morphogenesis of multiple organ systems in vertebrates, yet its role in CRC progression remains poorly understood. In the study, we found that LBX2 knockdown suppresses CRC proliferation in vitro and in vivo. ChIP-seq/RNA-seq identifies GFPT2 as a direct transcriptional target of LBX2. The LBX2/GFPT2 axis elevates UDP-GlcNAc levels and O-GlcNAcylation, promoting Raptor T700 glycosylation. This modification enhances mTORC1 activation by strengthening Raptor-Rag interactions, accelerating glycolysis and lactate production. Accumulated lactate induces histone H4K12 lactylation, which further upregulates LBX2 transcription, forming a positive feedback loop. Clinically, high LBX2 expression correlates with elevated PET-CT SUVmax values (indicating hyperglycolysis) in CRC patients. Patient-derived organoids with high LBX2 show increased sensitivity to the GLUT1 inhibitor. LBX2 thus serves as both a metabolic driver and a potential biomarker for CRC-targeted therapies.
样品范围 Multiisolate
发布日期 2025-10-10
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
41387417 LBX2 promotes colorectal cancer progression via the glycosylation and lactylation positive feedback Cell Death Discovery 10.1038/s41420-025-02888-w 2025
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
Jinhua Science and Technology Planning Project 2023-4-082
提交者 Haiping Lin (drlhp1994@163.com)
提交单位 Jinhua Central Hospital
提交日期 2025-10-10

项目包含数据信息

资源名称 描述
BioSample (22)  show -