| 项目编号 |
PRJCA048109 |
| 项目标题 |
Furin-Mediated Cleavage of Zona Pellucida Proteins Maintains oocyte integrity and supports oocyte survival |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
This project investigates the role of furin mediated cleavage of zona pellucida proteins in female fertility using a mouse model with a heterozygous mutation in Zp2. Disruption of the furin cleavage site in Zp2 leads to abnormal protein processing, impaired zona pellucida formation, and oocyte degeneration. Single cell RNA sequencing of ovaries from mutant and wild type mice was performed to explore transcriptional changes in folliculogenesis, oocyte maturation, and intercellular communication. The dataset provides insights into the molecular mechanisms linking defective post translational modification of zona pellucida proteins to female infertility. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2025-10-15 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41394961
|
Furin‐Mediated Cleavage of Zona Pellucida Proteins Is Essential for Oocyte Development
|
MedComm
|
10.1002/mco2.70542
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82471650
|
|
|
|
| 提交者 |
Xiang
Wang (wx029@outlook.com)
|
| 提交单位 |
West China Second University Hospital |
| 提交日期 |
2025-10-14 |
