| 项目编号 |
PRJCA048209 |
| 项目标题 |
A single-cell transcriptomic dataset profiling traumatic brain injury and NeuroD1-based gene therapy in mice |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Raw sequence reads
Single cell sequencing
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
To elucidate the molecular and cellular mechanisms involved, we conducted single-cell RNA sequencing using controlled cortical impact mice of TBI to compare the effects of vehicle treatment with those of NeuroD1-based gene therapy. Single-cell RNA sequencing reveals significant shifts in cellular composition and astrocyte subtypes. These changes involve upregulated synaptic assembly and myelination pathways alongside downregulated mitochondrial and metabolic functions in TBI mice. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-10-14 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
32571169
|
|
|
|
| 提交者 |
shuo
zhang (2921308279@qq.com)
|
| 提交单位 |
Jinan University |
| 提交日期 |
2025-10-14 |
