| 项目编号 |
PRJCA048417 |
| 项目标题 |
Extracellular matrix stiffness regulates the proliferation and migration capacities of lymphatic endothelial cells |
| 涉及领域 |
Medical |
| 数据类型 |
Genome sequencing
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
Extracellular matrix (ECM) stiffness is a critical biomechanical regulator of cellular behavior. However, its precise role in lymphatic endothelial cells (LECs) remains elusive, particularly in the context of tumorigenesis, where progressive stromal stiffening constitutes a hallmark of the tumor microenvironment (TME). To investigate the impact and elucidate the underlying mechanisms of ECM stiffness on LECs, we conducted transcriptomic analysis via high-throughput RNA sequencing on mouse LECs (SVEC 4-10) cultured for 48 hours on polyacrylamide hydrogels of varying stiffness. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2025-10-16 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41230499
|
Extracellular matrix stiffness regulates the proliferation and migration capacities of lymphatic endothelial cells via FAT1
|
Frontiers in Cell and Developmental Biology
|
10.3389/fcell.2025.1667154
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
81974446
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82073199
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82372710
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82273462
|
|
|
|
| 提交者 |
zhangrun
Xu (sjtuxzr1@sjtu.edu.cn)
|
| 提交单位 |
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine |
| 提交日期 |
2025-10-16 |
