| 项目编号 |
PRJCA048572 |
| 项目标题 |
Matrix Stiffness Drives Prostate Cancer Drug Resistance via Mitochondria-ER Contact-Mediated P-glycoprotein Regulation |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
This project aims to elucidate how increased extracellular matrix stiffness promotes drug resistance in prostate cancer. We hypothesize that stiff matrices enhance mitochondria-ER contact sites, leading to the upregulation of P-glycoprotein, a key drug efflux pump. Unraveling this pathway will identify novel therapeutic targets to overcome chemoresistance. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2025-10-18 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41362610
|
High matrix stiffness triggers the YAP-OPA1-TET1/3 loop to drive chemoresistance via enhanced nuclear-mitochondrial communication
|
iScience
|
10.1016/j.isci.2025.113996
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| China Postdoctoral Science Foundation
|
|
|
|
|
|
| 提交者 |
Peng
Wu (wupeng29@mail2.sysu.edu.cn)
|
| 提交单位 |
School of Medicine, Sun Yat-sen University |
| 提交日期 |
2025-10-17 |
