| 项目编号 |
PRJCA049342 |
| 项目标题 |
Metabolomic impact of maternal barium exposure on miscarriage |
| 涉及领域 |
Medical |
| 数据类型 |
Metabonomics
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
This project investigates the metabolic mechanisms underlying the association between maternal exposure to barium (Ba) and miscarriage. A total of 186 pregnant women were recruited, and both blood Ba levels and decidual tissue metabolomic profiles were analyzed using UHPLC-QExactiveHF-X mass spectrometry. Metabolome-wide association and mediation analyses identified key metabolites and pathways, including glycerophospholipid metabolism and oxidative stress-related metabolites. Five core metabolites were further used to construct a machine learning-based risk prediction model for miscarriage. The study provides new insights into environmental pollutant-induced reproductive toxicity and potential biomarkers for early miscarriage risk assessment. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-10-28 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41441287
|
Metabolomic Impact of Maternal Barium Exposure on Miscarriage Risk: Identification of Metabolic Biomarkers and Construction of a Risk Prediction Model
|
Toxics
|
10.3390/toxics13121066
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82273637
|
|
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
82304162
|
|
| Nanjing Health Science and Technology Development Project-Key Medical Science and Technology Development Project
|
|
ZKX21050
|
|
| Joint Funds of the National Natural Science Foundation of China
|
|
U22A20407
|
|
|
|
| 提交者 |
Qing
Xu (xuqing@njmu.edu.cn)
|
| 提交单位 |
Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital |
| 提交日期 |
2025-10-27 |
