| 项目编号 |
PRJCA049693 |
| 项目标题 |
Spatial Transcriptomics and Single-Cell Sequencing Analysis of Early-Stage Remodeling in Rabbit Carotid Arteries Following MnVGs Implantation. |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
Spatial Transcriptomics
|
| 物种名称 |
Oryctolagus cuniculus
|
| 描述信息 |
This study aims to investigate the cellular spatiotemporal distribution and fate during the post-implantation remodeling of artificial blood vessel (MnVGs) in a rabbit carotid artery model. The results provide insights into the cellular mechanisms governing MnVG remodeling and highlight its potential as a superior, self-remodeling graft by clarifying the spatiotemporal roadmap of cell participation and turnover. The observational objective of this study focuses on the spatiotemporal distribution and fate of cells during the remodeling process of MnVGs. All samples were neo-carotid arteries remodeled from 1.5 cm artificial vascular grafts (MnVGs) implanted into the carotid arteries of 3.5 kg male New Zealand rabbits. Single-cell sequencing samples were neo-carotid arteries at 1 week, 2 weeks, and 4 weeks post-implantation. Spatial transcriptome samples were neo-carotid arteries at 2 weeks and 4 weeks post-implantation. No replicates. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-12-08 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82071132
|
|
|
|
| 提交者 |
zheqian
zhang (18161982850@163.com)
|
| 提交单位 |
Air Force Medical University |
| 提交日期 |
2025-10-30 |
