| 项目编号 |
PRJCA049985 |
| 项目标题 |
CM-TAMs regulates TBLCs via BACH1/ANGPTL4/SDC4 |
| 涉及领域 |
Medical |
| 数据类型 |
Whole genome sequencing
|
| 物种名称 |
|
| 描述信息 |
This study reveals that tumor budding-like structures are common in chordomas and are closely associated with poor prognosis. Through multi-omics analysis and large-scale cohort validation, researchers identified a tumor budding-like cell subpopulation and uncovered its interaction with cholesterol metabolism tumor-associated macrophages. Mechanistically, BACH1-driven cholesterol metabolism tumor-associated macrophages secrete ANGPTL4, which activates tumor budding-like cells through SDC4, promoting their stemness, cholesterol accumulation, and malignant progression. In terms of treatment, inhibiting cholesterol metabolism or blocking the BACH1\ANGPTL4\SDC4 axis can suppress tumor invasiveness in preclinical models. Overall, this work redefines tumor budding-like structures as a key prognostic and mechanistic feature of chordomas and identifies a new immunometabolic signaling axis, providing potential therapeutic targets. |
| 样品范围 |
Single cell |
| 发布日期 |
2026-01-15 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41390963
|
Cholesterol-metabolic TAMs regulates tumor budding like cell subpopulation to promote chordoma stemness via BACH1/ANGPTL4/SDC4 axis
|
Neuro-oncology
|
10.1093/neuonc/noaf286
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China
|
|
82003802
|
|
| National Natural Science Foundation of China
|
|
82473965
|
|
| National Natural Science Foundation of China
|
|
82404690
|
|
| National Natural Science Foundation of China
|
|
82002364
|
|
| Natural Science Foundation of Hunan Province
|
|
2019JJ50542
|
|
| Natural Science Foundation of Hunan Province
|
|
2023JJ50156
|
|
| Natural Science Foundation of Hunan Province
|
|
2023JJ40596
|
|
| Natural Science Foundation of Hunan Province
|
|
2023JJ40587
|
|
| Natural Science Foundation of Hunan Province
|
|
2021JJ40509
|
|
| Hunan Provincial Natural Science Foundation for Excellent Youth Scholars
|
|
2023JJ20035
|
|
| the Science and Technology Innovation Program of Hunan Province
|
|
2023RC3172
|
|
|
|
| 提交者 |
Mingxiang
Zou (zoumx_spine@usc.edu.cn)
|
| 提交单位 |
First affiliated hospital of university of South China |
| 提交日期 |
2025-11-01 |
