| 项目编号 |
PRJCA050350 |
| 项目标题 |
Post-translational Switch of DHCR24 Acetylation Sustains Sterol Synthesis and Promotes HCC via 7-Ketocholesterol/p62 Axis |
| 涉及领域 |
Medical |
| 数据类型 |
Metabonomics
|
| 物种名称 |
Mus
|
| 描述信息 |
Dysregulated cholesterol synthesis links to cancer, but its HCC role is unclear. We find DHCR24 Lys254 acetylation (an HCC hallmark) predicts poor survival. It stabilizes DHCR24, boosts 7-ketocholesterol to upregulate p62, driving HCC growth. FDA-approved irbesartan inhibits DHCR24/its acetylation, suppressing HCC. This defines DHCR24 acetylation as a metabolic switch and the axis as an HCC target. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-11-07 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41348543
|
Post-translational switch of DHCR24 acetylation sustains sterol synthesis and promotes HCC via the 7-ketocholesterol/p62 axis
|
Cell Reports
|
10.1016/j.celrep.2025.116640
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82273225
|
|
|
|
| 提交者 |
Dabin
Liu (liudb526@126.com)
|
| 提交单位 |
NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy |
| 提交日期 |
2025-11-05 |
