| 项目编号 |
PRJCA051369 |
| 项目标题 |
A microbiota-host axis mediates prostaglandin sensitivity |
| 涉及领域 |
Medical |
| 数据类型 |
Metagenome
|
| 物种名称 |
|
| 描述信息 |
Labor induction failure increases the risk of unplanned cesarean delivery and maternal-neonatal complications. However, the determinants of induction sensitivity remain poorly understood. In this prospective cohort of 85 term pregnant women undergoing labor induction with Propess (prostaglandin E2), we combined full-length 16S rRNA sequencing of the vaginal microbiota, untargeted metabolomics of vaginal secretions, and transcriptomic analysis of cervical stromal cells exposed to Lactobacillus crispatus supernatant to identify predictive factors and underlying mechanisms. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2026-01-20 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82403347
|
|
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2022YFC2704402
|
|
|
|
| 提交者 |
Wencheng
Ding (dingwencheng326@163.com)
|
| 提交单位 |
Tongji hospital of Tongji Medical College of Huazhong University of Science and Technology |
| 提交日期 |
2025-11-17 |
