| Accession |
PRJCA051673 |
| Title |
Target anmino acid metabolism |
| Relevance |
Medical |
| Data types |
Metabonomics
|
| Organisms |
Homo sapiens
|
| Description |
Emerging evidence demonstrates that chronic stress alters immunological, neurochemical and endocrinological functions, thereby promoting tumor progression. However, the underlying metabolic mechanism of chronic stress in tumor progression is still elusive. Using multi-omics analysis, we found that aminopeptidase N (ANPEP) was upregulated in tumors with chronic restraint, associating with the reprogramming of amino acid metabolism. |
| Sample scope |
Monoisolate |
| Release date |
2025-11-20 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 41329521
|
Chronic stress–induced ANPEP drives liver cancer progression by increasing glutathione synthesis and inhibiting ferroptosis
|
The Journal of Clinical Investigation
|
10.1172/JCI195685
|
2025
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
NA
|
|
|
|
| Submitter |
Yongkang
Wu (418021579@qq.com)
|
| Organization |
School of Basic Medical Sciences |
| Submission date |
2025-11-20 |
