| 项目编号 |
PRJCA052071 |
| 项目标题 |
Decoding the dynamic social networks of complex microbial communities at single-cell resolution |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
human gut metagenome
|
| 描述信息 |
Microbial communities function as dynamic societies where intercellular communication governs collective behaviors, yet mapping these interaction networks has remained a fundamental challenge in microbiology. Here we decode the social networks of complex bacterial communities at single-cell resolution by developing BACON, a computational framework that infers quorum sensing-mediated communication from single-microbe transcriptomic data. Our approach combines a curated database of signaling systems with a statistical model that quantifies communication strength through coordinated expression of signal synthesis and receptor genes. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-11-25 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82402729
|
|
|
|
| 提交者 |
Yifei
Shen (yifeishen@zju.edu.cn)
|
| 提交单位 |
The First Affiliated Hospital, Zhejiang University School of Medicine |
| 提交日期 |
2025-11-25 |
