| 描述信息 |
Acinetobacter baumannii, a critical nosocomial pathogen, relies heavily on biofilm formation for survival in healthcare environments, enhancing its resistance to antibiotics and host immunity. Mounting evidence highlights the pivotal role of metabolites in mediating biofilm development, from initial attachment to mature community stabilization. Key metabolites, including quorum-sensing molecules (e.g., N-acylhomoserine lactones), exopolysaccharides (EPS), and amino acids (e.g., tryptophan and arginine), orchestrate this complex process. Disrupting this metabolite-biofilm crosstalk represents a promising therapeutic strategy to combat A. baumannii infections, underscoring the need for further research into the metabolic networks governing biofilm pathogenesis. |
