| 项目编号 |
PRJCA053981 |
| 项目标题 |
The utility of integrating CNA/CN-LOH and mutational profiles in prognostic stratification of elderly NPM1-mutated acute myeloid leukemia |
| 涉及领域 |
Medical |
| 数据类型 |
Whole genome sequencing
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| 物种名称 |
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| 描述信息 |
Acute myeloid leukemia(AML) exhibits substanrial genetic heterogeneity in elderly patients. Despite validated genomic alterations facilitating refined precision prognostication, incomplete intergration of genetic profiles, particularly underutilization of copy number alterations(CNAs) and copy-neutral loss of heterozygosity (CN-LOH), remains a source of prognostic uncertainty in elderly patiens with NPM1-mutated AML. To address this gap, we conducted an exploratory study. Shallow whole-genome sequencing (sWGS) was used for CNA/CN-LOH detection. Genomic data were integrated with clinical and laboratory variables to evaluate the prognostic utility of combining CNA/CN-LOH burden. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-12-18 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| No funding support
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| 提交者 |
Zhenling
Li (13911826393@163.com)
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| 提交单位 |
China-Japan Friendship Hospital |
| 提交日期 |
2025-12-18 |
