| 项目编号 |
PRJCA054893 |
| 项目标题 |
A1TP-HX-EVs target and repair intervertebral disc degeneration |
| 涉及领域 |
Medical |
| 数据类型 |
Metabonomics
|
| 物种名称 |
|
| 描述信息 |
We identified the membrane protein ADGRG1 as a biomarker of ROS-induced ferroptosis in injured NPCs and developed A1TP-modified hypoxia preconditioned extracellular vesicles (HX-EVs) with targeted antioxidant therapeutic potential. We used LC-MS/MS analysis to identify the compositional differences between HX-EVs and EVs, and applied A1TP-HX-EVs to selectively repair TBHP (ROS)-induced injury in nucleus pulposus cells |
| 样品范围 |
Multiisolate |
| 发布日期 |
2026-03-07 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41756689
|
ADGRG1-targeted hypoxia preconditioned extracellular vesicles ameliorate intervertebral disc degeneration by delivering taurine to disrupt the oxidative stress feedback loop-driven ferroptosis in nucleus pulposus cells
|
Bioactive Materials
|
10.1016/j.bioactmat.2026.02.029
|
2026
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| No funding support
|
|
|
|
|
|
| 提交者 |
Shang
Chen (chenshang2010@163.com)
|
| 提交单位 |
Affiliated Hospital of Jining Medical University |
| 提交日期 |
2025-12-31 |
