| 项目编号 |
PRJCA055175 |
| 项目标题 |
Study on the effect and mechanism of Ershiyiwei Lvronghao Concentrated Pills in the treatment of nonalcoholic fatty liver disease |
| 涉及领域 |
Medical |
| 数据类型 |
metabonomics
|
| 物种名称 |
|
| 描述信息 |
Metabolomic analysis was performed using liquid chromatography-mass spectrometry (LC-MS) following established protocols. Quality control samples were prepared by pooling equal volumes of each AH sample to assess the stability and reproducibility of the untargeted metabolic analysis. The current untargeted metabolic analysis was performed via LC-MS. For LC-MS, an AWaters ACQUITY UPLC I-Class plus/Thermo QE HF coupled with a VION IMS QTOF Mass spectrometer (Waters Corporation, Milford, USA) was used to analyze the metabolic profiling in both ESI positive and ESI negative ion modes. An ACQUITY UPLC HSS T3 column was employed in both positive and negative modes. All raw data were imported into MS-DIAL software and Progenesis QI V2.3 software (Nonlinear, Dynamics, Newcastle, UK) for further identification processing. The missing values in the raw data were filled by using half of the minimum value. The identification of metabolites from GC-MS was based on the LUG database, while the detection of compounds by LC-MS was performed based on the Human Metabolome Database (HMDB), Metlin, PMDB, and self-built databases. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2026-01-05 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Study on the effect and mechanism of Ershiyiwei Lvronghao concentrated Pills in the treatment of nonalcoholic fatty liver disease
|
Frontiers in Pharmacology
|
10.3389/fphar.2025.1725610
|
2026
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Science and Technology Projects of Xizang Axtonomoxs Region
|
|
XZ202301YD0014C
|
|
| Science and Technology Projects of Xizang Axtonomoxs Region
|
|
XZ202401YD0022
|
|
| Science and Technology Projects of Xizang Axtonomoxs Region
|
|
XZ202301ZY0007G
|
|
| Science and Technology Projects of Xizang Axtonomoxs Region
|
|
XZ202301ZY0009G
|
|
| Science and Technology Projects of Xizang Axtonomoxs Region
|
|
XZ202201ZD0001G01/06
|
|
| Science and Technology Projects of Xizang Axtonomoxs Region
|
|
XZ202303ZY0007G
|
|
| the National Natural Science Foundation of China
|
|
U23A20516
|
|
| the Sichuan Provincial Regional Innovation Cooperation Project
|
|
2023YFQ0042
|
|
| the Xizang Autonomous Region Key R&D Program
|
|
XZ202301ZY0043G
|
|
|
|
| 提交者 |
Yexin
Wu (wuyxdyx@163.com)
|
| 提交单位 |
Sichuan University West China School of Pharmacy |
| 提交日期 |
2026-01-05 |
