| 项目编号 |
PRJCA056162 |
| 项目标题 |
Metabolomics data: A microbiota-host axis mediates prostaglandin sensitivity |
| 涉及领域 |
Medical |
| 数据类型 |
Metabonomics
|
| 物种名称 |
|
| 描述信息 |
Labor induction failure increases the risk of unplanned cesarean delivery and maternal-neonatal complications. However, the determinants of induction sensitivity remain poorly understood. In this prospective cohort of 85 term pregnant women undergoing labor induction with Propess (prostaglandin E2), we combined full-length 16S rRNA sequencing of the vaginal microbiota, untargeted metabolomics of vaginal secretions, and transcriptomic analysis of cervical stromal cells exposed to Lactobacillus crispatus supernatant to identify predictive factors and underlying mechanisms. This BioProject contains metabolomics data. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2026-01-20 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41839898
|
A microbiota–host axis mediates prostaglandin sensitivity: Lactobacillus crispatus as a biomarker and regulator of human labor induction
|
NPJ Biofilms and Microbiomes
|
10.1038/s41522-026-00960-6
|
2026
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82403347
|
|
|
|
| 提交者 |
Wencheng
Ding (dingwencheng326@163.com)
|
| 提交单位 |
Tongji hospital of Tongji Medical College of Huazhong University of Science and Technology |
| 提交日期 |
2026-01-18 |
