| 项目编号 |
PRJCA058404 |
| 项目标题 |
Integrated Metabolomic and Transcriptomic Analysis Reveals Novel Plasma Biomarkers and Metabolic Pathway Dysregulation in Latent Tuberculosis Infection |
| 涉及领域 |
Medical |
| 数据类型 |
Biomarkers
Metabonomics
|
| 物种名称 |
|
| 描述信息 |
This project aims to investigate metabolic and transcriptomic alterations associated with latent tuberculosis infection (LTBI) in humans. A total of 166 participants, including 81 LTBI individuals and 85 healthy controls, were recruited. Untargeted plasma metabolomics profiling was performed using LC-MS/MS in both positive and negative ion modes. Integrated multi-omics analysis was conducted to identify differential metabolites, explore dysregulated metabolic pathways, and discover potential diagnostic biomarkers for LTBI. The project provides raw mass spectrometry data, processed feature tables, and associated metadata to support reproducibility and secondary analyses. The findings contribute to understanding host metabolic reprogramming during latent Mycobacterium tuberculosis infection and offer insights into early diagnosis strategies. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2026-02-12 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Integrated metabolomic and transcriptomic analysis reveals novel plasma biomarkers and metabolic pathway dysregulation in latent tuberculosis infection
|
Microbiology Spectrum
|
10.1128/spectrum.03482-25
|
2026
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
8130144
|
|
|
|
| 提交者 |
Dong
Liu (649395940@qq.com)
|
| 提交单位 |
China Pharmaceutical University |
| 提交日期 |
2026-02-12 |
