| 项目编号 | PRJCA059054 | ||||||||||||
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| 项目标题 | Enhancing Antitumor Nanovaccine Efficacy via Integrated Cholesterol Modulation In Situ | ||||||||||||
| 涉及领域 | Medical | ||||||||||||
| 数据类型 | Transcriptome or Gene expression | ||||||||||||
| 物种名称 | |||||||||||||
| 描述信息 | Antigen presentation is a central component of host immune responses to cancer vaccinations; however, antigen-presenting cells (APCs) often fail to promote sufficient proliferation of specific T cells, thus restricting their efficacy. This study demonstrated that manipulating the dendritic cell (DC) membrane cholesterol levels could enhance antigen-presenting capability. Based on this finding, a membrane cholesterol-depleting nanovaccine designed to deliver antigen to DCs and simultaneously reduce membrane cholesterol was developed. | ||||||||||||
| 样品范围 | Monoisolate | ||||||||||||
| 发布日期 | 2026-03-01 | ||||||||||||
| 项目资金来源 |
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| 提交者 | YongKang Wang (wyk0035@126.com) | ||||||||||||
| 提交单位 | Huazhong Agricultural University | ||||||||||||
| 提交日期 | 2026-02-28 |