| 项目编号 | PRJCA061169 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 项目标题 | Functional targeting of PTTG1 in pericytes restores vascular integrity in diabetic retina | ||||||||
| 涉及领域 | Medical | ||||||||
| 数据类型 |
Transcriptome or Gene expression
Raw sequence reads Single cell sequencing |
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| 物种名称 | |||||||||
| 描述信息 | Pericyte loss is an early event in diabetic retinopathy, but the underlying mechanisms remain unclear. Single-cell RNA sequencing of retinal cells identified a PTTG1-high pericyte subpopulation that was enriched in diabetic mice. Integrated transcriptomic and metabolomic analyses showed that PTTG1 silencing reprogrammed cellular metabolism, altering glycolytic flux and reducing oxidative stress. | ||||||||
| 样品范围 | Multispecies | ||||||||
| 发布日期 | 2026-04-01 | ||||||||
| 项目资金来源 |
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| 提交者 | Biao Yan (yanbiaolab@outlook.com) | ||||||||
| 提交单位 | Shanghai General Hospital | ||||||||
| 提交日期 | 2026-03-31 |