项目编号

PRJEB23709

项目标题

Biomarkers of response and resistance to checkpoint blockade immunotherapy in metastatic melanoma

数据类型

Other

样品范围

Monoisolate

描述信息

Identifying the mechanistic features that determine a cancer patient's response to immune checkpoint inhibitors is a critical step towards improving the efficacy of current therapies and optimising the design of clinical trials for next-generation drugs. Here, we investigated the transcriptomic and immunophenotypic profiles of metastatic melanoma patients treated with anti-PD-1 alone or combined anti-PD-1 and anti-CTLA-4 immunotherapy. Effector T-cells are essential for increased anti-cancer activity, favouring better survival outcomes in patients treated with anti-PD-1 monotherapy. In contrast, response to combined anti-PD-1 and anti-CTLA-4 immunotherapy relied upon memory cytotoxic and helper T-cell populations. Patients with resistance to immune checkpoint blockade exploited the metabolic and hypoxia-mediated pathways to alter tumour microenvironment causing impairment of T-cell trafficking and function. Our findings provide a strong rationale for stratifying patients based on molecular profiles that determine response and resistance to anti-PD1 alone or in combination with anti-CTLA-4 immunotherapy.

出版信息

PubMed ID	文章标题	杂志名称	Doi	发表年份
30753825	Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy.	Cancer cell		2019

发布日期

2019-02-14

提交单位

Melanoma Institute Australia

数据来源

NCBI

项目包含数据信息

资源名称	描述
Experiment (91) show	-
ERX2263246	Illumina HiSeq 2500 paired end sequencing
ERX2263247	Illumina HiSeq 2500 paired end sequencing
ERX2263245	Illumina HiSeq 2500 paired end sequencing
ERX2263249	Illumina HiSeq 2500 paired end sequencing
ERX2263250	Illumina HiSeq 2500 paired end sequencing
ERX2263248	Illumina HiSeq 2500 paired end sequencing
ERX2263252	Illumina HiSeq 2500 paired end sequencing
ERX2263253	Illumina HiSeq 2500 paired end sequencing
ERX2263251	Illumina HiSeq 2500 paired end sequencing
ERX2263255	Illumina HiSeq 2500 paired end sequencing
ERX2263256	Illumina HiSeq 2500 paired end sequencing
ERX2263254	Illumina HiSeq 2500 paired end sequencing
ERX2263258	Illumina HiSeq 2500 paired end sequencing
ERX2263259	Illumina HiSeq 2500 paired end sequencing
ERX2263257	Illumina HiSeq 2500 paired end sequencing
ERX2263262	Illumina HiSeq 2500 paired end sequencing
ERX2263260	Illumina HiSeq 2500 paired end sequencing
ERX2263264	Illumina HiSeq 2500 paired end sequencing
ERX2263265	Illumina HiSeq 2500 paired end sequencing
ERX2263263	Illumina HiSeq 2500 paired end sequencing
ERX2263267	Illumina HiSeq 2500 paired end sequencing
ERX2263268	Illumina HiSeq 2500 paired end sequencing
ERX2263266	Illumina HiSeq 2500 paired end sequencing
ERX2263270	Illumina HiSeq 2500 paired end sequencing
ERX2263271	Illumina HiSeq 2500 paired end sequencing
ERX2263269	Illumina HiSeq 2500 paired end sequencing
ERX2263272	Illumina HiSeq 2500 paired end sequencing
ERX2263273	Illumina HiSeq 2500 paired end sequencing
ERX2263274	Illumina HiSeq 2500 paired end sequencing
ERX2263276	Illumina HiSeq 2500 paired end sequencing
ERX2263277	Illumina HiSeq 2500 paired end sequencing
ERX2263278	Illumina HiSeq 2500 paired end sequencing
ERX2263281	Illumina HiSeq 2500 paired end sequencing
ERX2263279	Illumina HiSeq 2500 paired end sequencing
ERX2263280	Illumina HiSeq 2500 paired end sequencing
ERX2263282	Illumina HiSeq 2500 paired end sequencing
ERX2263284	Illumina HiSeq 2500 paired end sequencing
ERX2263286	Illumina HiSeq 2500 paired end sequencing
ERX2263287	Illumina HiSeq 2500 paired end sequencing
ERX2263288	Illumina HiSeq 2500 paired end sequencing
ERX2263285	Illumina HiSeq 2500 paired end sequencing
ERX2263289	Illumina HiSeq 2500 paired end sequencing
ERX2263292	Illumina HiSeq 2500 paired end sequencing
ERX2263294	Illumina HiSeq 2500 paired end sequencing
ERX2263295	Illumina HiSeq 2500 paired end sequencing
ERX2263293	Illumina HiSeq 2500 paired end sequencing
ERX2263297	Illumina HiSeq 2500 paired end sequencing
ERX2263296	Illumina HiSeq 2500 paired end sequencing
ERX2263299	Illumina HiSeq 2500 paired end sequencing
ERX2263300	Illumina HiSeq 2500 paired end sequencing
ERX2263298	Illumina HiSeq 2500 paired end sequencing
ERX2263302	Illumina HiSeq 2500 paired end sequencing
ERX2263303	Illumina HiSeq 2500 paired end sequencing
ERX2263304	Illumina HiSeq 2500 paired end sequencing
ERX2263301	Illumina HiSeq 2500 paired end sequencing
ERX2263305	Illumina HiSeq 2500 paired end sequencing
ERX2263306	Illumina HiSeq 2500 paired end sequencing
ERX2263307	Illumina HiSeq 2500 paired end sequencing
ERX2263309	Illumina HiSeq 2500 paired end sequencing
ERX2263310	Illumina HiSeq 2500 paired end sequencing
ERX2263311	Illumina HiSeq 2500 paired end sequencing
ERX2263314	Illumina HiSeq 2500 paired end sequencing
ERX2263312	Illumina HiSeq 2500 paired end sequencing
ERX2263316	Illumina HiSeq 2500 paired end sequencing
ERX2263317	Illumina HiSeq 2500 paired end sequencing
ERX2263315	Illumina HiSeq 2500 paired end sequencing
ERX2263319	Illumina HiSeq 2500 paired end sequencing
ERX2263320	Illumina HiSeq 2500 paired end sequencing
ERX2263318	Illumina HiSeq 2500 paired end sequencing
ERX2263322	Illumina HiSeq 2500 paired end sequencing
ERX2263323	Illumina HiSeq 2500 paired end sequencing
ERX2263321	Illumina HiSeq 2500 paired end sequencing
ERX2263324	Illumina HiSeq 2500 paired end sequencing
ERX2263291	Illumina HiSeq 2500 paired end sequencing
ERX2263290	Illumina HiSeq 2500 paired end sequencing
ERX2263261	Illumina HiSeq 2500 paired end sequencing
ERX2263325	Illumina HiSeq 2500 paired end sequencing
ERX2263326	Illumina HiSeq 2500 paired end sequencing
ERX2263327	Illumina HiSeq 2500 paired end sequencing
ERX2263328	Illumina HiSeq 2500 paired end sequencing
ERX2263329	Illumina HiSeq 2500 paired end sequencing
ERX2263330	Illumina HiSeq 2500 paired end sequencing
ERX2263331	Illumina HiSeq 2500 paired end sequencing
ERX2263332	Illumina HiSeq 2500 paired end sequencing
ERX2263333	Illumina HiSeq 2500 paired end sequencing
ERX2263335	Illumina HiSeq 2500 paired end sequencing
ERX3289215	Illumina HiSeq 2500 paired end sequencing
ERX3289218	Illumina HiSeq 2500 paired end sequencing
ERX3289217	Illumina HiSeq 2500 paired end sequencing
ERX3289219	Illumina HiSeq 2500 paired end sequencing
ERX3289216	Illumina HiSeq 2500 paired end sequencing