| Accession |
PRJNA1073870 |
| Title |
Aging aggravates aortic aneurysm and dissection via miR-1204-MYLK signaling axis |
| Relevance |
Medical |
| Data types |
Epigenomics |
| Sample scope |
Multiisolate |
| Organism |
Homo sapiens [Taxonomy ID: 9606]
|
| Description |
The mechanism by which aging induces aortic aneurysm and dissection (AAD) remains unclear. We found that miR-1204 was significantly increased in both plasma and aorta of elder patients with AAD, and was positively correlated with age. Cell senescence induced the expression of miR-1204 through p53 interaction with plasmacytoma variant translocation 1, and miR-1204 induced vascular smooth muscle cell (VSMC) senescence to form a positive feedback loop.
Overall design: Chromatin immunoprecipitation DNA sequencing for target genes binding to p53 in miR-1204 overexpressing or control vascular smooth muscle cells. |
| External link |
|
| Organization |
Surgery/Cardiac Surgery, The First Affiliated Hospital, Sun Yat-sen University |
| Data Source |
NCBI |
