Accession PRJNA1073870
Title Aging aggravates aortic aneurysm and dissection via miR-1204-MYLK signaling axis
Relevance Medical
Data types Epigenomics
Sample scope Multiisolate
Organism Homo sapiens [Taxonomy ID: 9606]
Description The mechanism by which aging induces aortic aneurysm and dissection (AAD) remains unclear. We found that miR-1204 was significantly increased in both plasma and aorta of elder patients with AAD, and was positively correlated with age. Cell senescence induced the expression of miR-1204 through p53 interaction with plasmacytoma variant translocation 1, and miR-1204 induced vascular smooth muscle cell (VSMC) senescence to form a positive feedback loop. Overall design: Chromatin immunoprecipitation DNA sequencing for target genes binding to p53 in miR-1204 overexpressing or control vascular smooth muscle cells.
External link
Link description
Organization Surgery/Cardiac Surgery, The First Affiliated Hospital, Sun Yat-sen University
Data Source NCBI

Project Data

Resource name Description
Experiment (4) -
SRX23548769 GSM8064821: VSMC, miR-ctl, input; Homo sapiens; ChIP-Seq
SRX23548768 GSM8064820: VSMC, miR-ctl, ChIP; Homo sapiens; ChIP-Seq
SRX23548771 GSM8064823: VSMC, miR-1204, input; Homo sapiens; ChIP-Seq
SRX23548770 GSM8064822: VSMC, miR-1204, ChIP; Homo sapiens; ChIP-Seq