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项目编号 PRJNA1100531
项目标题 Cell sorting based on single nucleotide variation enables mutation-driven characterization of transcriptome and chromatin states
涉及领域 Medical
数据类型 Raw sequence reads
样品范围 Multispecies
描述信息 To enable studies of rare population of cell harboring specific point mutations, we developed STAR-FACS, Specific-To-Allele PCR-FACS. This method allows for labeling cells based on allele-specific genomic DNA in-cell amplification. Labeled cells are then sorted and profiled with bulk or single cell transcriptomics. Moreover, the protocol is also compatible with downstream characterization of chromatin features with Cleavage Under Targets and Tagmentation (CUT&Tag) method. Our proof-of-principle study shows that STAR-FACS can be used to separate cells based on TERT promoter mutation status.
发布日期 2024-04-15
提交单位 Wertheim UF Scripps Institute
数据来源 NCBI

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