Accession PRJNA837373
Title Transcriptome changes following treatment of three human cancer cell lines (U-2 OS, NCI-H460, A375) with actinomycin D and nutlin-3a.
Relevance Medical
Data types Raw sequence reads
Sample scope Multispecies
Description Actinomycin D and nutlin-3a act synergistically in activation of p53 transcription factor and, consequently, synergistically activate a subset of p53-regulated genes. The goal was to compare transcriptome changes of cell lines derived from three different cancers. The cells grew in control conditions or were exposed for 30 hours to 5nM actinomycin D and 5 uM nutlin-3a.
Organization Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch
Data Source NCBI

Project Data

Resource name Description
Experiment (6)  show -