Accession	PRJNA837373
Title	Transcriptome changes following treatment of three human cancer cell lines (U-2 OS, NCI-H460, A375) with actinomycin D and nutlin-3a.
Relevance	Medical
Data types	Raw sequence reads
Sample scope	Multispecies
Description	Actinomycin D and nutlin-3a act synergistically in activation of p53 transcription factor and, consequently, synergistically activate a subset of p53-regulated genes. The goal was to compare transcriptome changes of cell lines derived from three different cancers. The cells grew in control conditions or were exposed for 30 hours to 5nM actinomycin D and 5 uM nutlin-3a.
Organization	Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch
Data Source	NCBI

Project Data

Resource name	Description
Experiment (6) show	-
SRX15239900	RNA-Seq of U2OS cell line in control conditions
SRX15239901	RNA-Seq of U2OS cell line exposed to 5nM actinomycin D and 5 uM nutlin-3a
SRX15239902	RNA-Seq of NCI-H460 cell line in control conditions
SRX15239903	RNA-Seq of NCI-H460 cell line exposed to 5nM actinomycin D and 5 uM nutlin-3a
SRX15239904	RNA-Seq of A-375 cell line in control conditions
SRX15239905	RNA-Seq of A-375 cell line exposed to 5nM actinomycin D and 5 uM nutlin-3a