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Accession PRJNA912682
Title Epidemiology and impact of emerging Campylobacter species isolated from humans and animals in Loreto Department Peru: Genome sequencing and assembly
Relevance Medical
Data types Genome sequencing and assembly
Sample scope Multispecies
Description Despite clear evidence that Campylobacter is a principal cause of enteritis in the developing world, advanced approaches in source attribution have not been employed to identify sources of infection causing disease in humans, or to identify the sources of human infections resistant to both fluoroquinolones and azithromycin (MDR Campylobacter), despite their documented high incidence. The limited genomic study of Campylobacter done in low and middle income countries demonstrate important differences in the genomes of isolates from both humans and zoonotic sources, indicating that transmission dynamics differ in these settings compared to that seen in high income countries and the current deficit in accurate identification of zoonotic source populations where most infections are linked is a critical knowledge gap in the global control of Campylobacter infections. The objective of this project is to inform targeted disease control measures to reduce the impact of campylobacteriosis and human MDR Campylobacter in low and middle income countries. Our central hypothesis is that industrially produced meat products are the principal source of campyobacteriosis and MDR Campylobacter in humans in this population. In order to test our central hypothesis we will 1) identify host segregating features of Campylobacter from zoonotic sources from putative zoonotic sources in Peru; 2) characterize the genomes of Campylobacter causing moderate to severe disease in children and MDR infections and 3) estimate the burden of campylobacteriosis and human MDR infections attributable to domestic and industrial zoonotic sources.
Organization AB PRISMA
Data Source NCBI

Project Data

Resource name Description
Experiment (134)  show -