Accession	PRJNA946035
Title	Whole genome enrichment of Mycobacterium tuberculosis using CNERs
Relevance	Medical
Data types	Raw sequence reads
Sample scope	Multispecies
Description	We developed a cost-effective method named Circular Nucleic acid Enrichment Reagent synthesis (CNERs) to generate whole-genome enrichment probes. We demonstrated the method by producing probes for Mycobacterium tuberculosis which we used to enrich M. tuberculosis DNA that had been spiked at concentrations as low as 0.01% and 100 genome copies against human DNA background to 1225-fold and 4636-fold. Further, we also enriched DNA from different M. tuberculosis lineages and M. bovis and demonstrated the utility of the WGE-CNERs data for lineage identification and drug-resistance characterization using an established pipeline. We conclude that our probe generation method for whole-genome enrichment will be a valuable tool for genomic epidemiology of emerging and difficult-to-grow pathogens.
Organization	University of California Santa Cruz
Data Source	NCBI

Project Data

Resource name	Description
Experiment (310) show	-
SRX19713667	Shotgun sequencing of Mycobacteria
SRX19713668	Whole genome enrichment of Mycobacteria using CNERs
SRX19713666	Shotgun sequencing of Mycobacteria
SRX19713670	Whole genome enrichment of Mycobacteria using CNERs
SRX19713671	Shotgun sequencing of Mycobacteria
SRX19713669	Whole genome enrichment of Mycobacteria using CNERs
SRX19713673	Shotgun sequencing of Mycobacteria
SRX19713674	Shotgun sequencing of Mycobacteria
SRX19713672	Shotgun sequencing of Mycobacteria
SRX19713676	Whole genome enrichment of Mycobacteria using CNERs
SRX19713677	Whole genome enrichment of Mycobacteria using CNERs
SRX19713675	Whole genome enrichment of Mycobacteria using CNERs
SRX19713679	Whole genome enrichment of Mycobacteria using CNERs
SRX19713680	Shotgun sequencing of Mycobacteria
SRX19713678	Whole genome enrichment of Mycobacteria using CNERs
SRX19713682	Shotgun sequencing of Mycobacteria
SRX19713683	Shotgun sequencing of Mycobacteria
SRX19713681	Shotgun sequencing of Mycobacteria
SRX19713687	Whole genome enrichment of Mycobacteria using CNERs
SRX19713685	Whole genome enrichment of Mycobacteria using CNERs
SRX19713686	Whole genome enrichment of Mycobacteria using CNERs
SRX19713684	Whole genome enrichment of Mycobacteria using CNERs
SRX19713691	Shotgun sequencing of Mycobacteria
SRX19713689	Shotgun sequencing of Mycobacteria
SRX19713690	Whole genome enrichment of Mycobacteria using CNERs
SRX19713688	Shotgun sequencing of Mycobacteria
SRX19713695	Whole genome enrichment of Mycobacteria using CNERs
SRX19713693	Whole genome enrichment of Mycobacteria using CNERs
SRX19713694	Whole genome enrichment of Mycobacteria using CNERs
SRX19713692	Shotgun sequencing of Mycobacteria
SRX19713697	Whole genome enrichment of Mycobacteria using CNERs
SRX19713698	Whole genome enrichment of Mycobacteria using CNERs
SRX19713696	Whole genome enrichment of Mycobacteria using CNERs
SRX19713700	Whole genome sequencing of Mycobacteria
SRX19713701	Shotgun sequencing of Mycobacteria
SRX19713699	Whole genome enrichment of Mycobacteria using CNERs
SRX19713705	Shotgun sequencing of Mycobacteria
SRX19713703	Shotgun sequencing of Mycobacteria
SRX19713704	Whole genome enrichment of Mycobacteria using CNERs
SRX19713702	Shotgun sequencing of Mycobacteria
SRX19713707	Whole genome enrichment of Mycobacteria using CNERs
SRX19713708	Whole genome enrichment of Mycobacteria using CNERs
SRX19713709	Whole genome enrichment of Mycobacteria using CNERs
SRX19713706	Whole genome enrichment of Mycobacteria using CNERs
SRX19713710	Whole genome enrichment of Mycobacteria using CNERs
SRX19713711	Whole genome enrichment of Mycobacteria using CNERs
SRX19713712	Whole genome enrichment of Mycobacteria using CNERs
SRX19713713	Whole genome enrichment of Mycobacteria using CNERs
SRX19713714	Whole genome enrichment of Mycobacteria using CNERs
SRX19713718	Shotgun sequencing of Mycobacteria
SRX19713715	Whole genome enrichment of Mycobacteria using CNERs
SRX19713716	Whole genome enrichment of Mycobacteria using CNERs
SRX19713719	Shotgun sequencing of Mycobacteria
SRX19713720	Shotgun sequencing of Mycobacteria
SRX19713717	Shotgun sequencing of Mycobacteria
SRX19713722	Whole genome enrichment of Mycobacteria using CNERs
SRX19713723	Whole genome enrichment of Mycobacteria using CNERs
SRX19713721	Whole genome enrichment of Mycobacteria using CNERs
SRX19713725	Whole genome enrichment of Mycobacteria using CNERs
SRX19713726	Whole genome enrichment of Mycobacteria using CNERs
SRX19713728	Whole genome enrichment of Mycobacteria using CNERs
SRX19713729	Whole genome enrichment of Mycobacteria using CNERs
SRX19713727	Whole genome enrichment of Mycobacteria using CNERs
SRX19713731	Whole genome enrichment of Mycobacteria using CNERs
SRX19713732	Whole genome sequencing of Mycobacteria
SRX19713730	Whole genome enrichment of Mycobacteria using CNERs
SRX19713734	Whole genome enrichment of Mycobacteria using CNERs
SRX19713735	Whole genome enrichment of Mycobacteria using CNERs
SRX19713733	Whole genome enrichment of Mycobacteria using CNERs
SRX19713737	Whole genome enrichment of Mycobacteria using CNERs
SRX19713738	Whole genome enrichment of Mycobacteria using CNERs
SRX19713736	Shotgun sequencing of Mycobacteria
SRX19713742	Whole genome enrichment of Mycobacteria using CNERs
SRX19713740	Whole genome enrichment of Mycobacteria using CNERs
SRX19713741	Whole genome enrichment of Mycobacteria using CNERs
SRX19713739	Whole genome enrichment of Mycobacteria using CNERs
SRX19713744	Whole genome sequencing of Mycobacteria
SRX19713745	Shotgun sequencing of Mycobacteria
SRX19713743	Whole genome enrichment of Mycobacteria using CNERs
SRX19713747	Shotgun sequencing of Mycobacteria
SRX19713750	Whole genome enrichment of Mycobacteria using CNERs
SRX19713748	Shotgun sequencing of Mycobacteria
SRX19713746	Shotgun sequencing of Mycobacteria
SRX19713751	Whole genome sequencing of Mycobacteria
SRX19713752	Shotgun sequencing of Mycobacteria
SRX19713749	Whole genome enrichment of Mycobacteria using CNERs
SRX19713754	Shotgun sequencing of Mycobacteria
SRX19713755	Shotgun sequencing of Mycobacteria
SRX19713753	Shotgun sequencing of Mycobacteria
SRX19713757	Whole genome enrichment of Mycobacteria using CNERs
SRX19713758	Whole genome enrichment of Mycobacteria using CNERs
SRX19713756	Shotgun sequencing of Mycobacteria
SRX19713724	Whole genome enrichment of Mycobacteria using CNERs
SRX19713760	Whole genome enrichment of Mycobacteria using CNERs
SRX19713761	Whole genome enrichment of Mycobacteria using CNERs
SRX19713759	Whole genome enrichment of Mycobacteria using CNERs
SRX19713763	Whole genome enrichment of Mycobacteria using CNERs
SRX19713764	Whole genome enrichment of Mycobacteria using CNERs
SRX19713762	Whole genome enrichment of Mycobacteria using CNERs
SRX19713768	Whole genome enrichment of Mycobacteria using CNERs
SRX19713766	Whole genome enrichment of Mycobacteria using CNERs
SRX19713767	Whole genome enrichment of Mycobacteria using CNERs
SRX19713765	Whole genome enrichment of Mycobacteria using CNERs
SRX19713772	Shotgun sequencing of Mycobacteria
SRX19713770	Whole genome sequencing of Mycobacteria
SRX19713771	Shotgun sequencing of Mycobacteria
SRX19713769	Whole genome enrichment of Mycobacteria using CNERs
SRX19713773	Shotgun sequencing of Mycobacteria
SRX19713774	Shotgun sequencing of Mycobacteria
SRX19713775	Whole genome enrichment of Mycobacteria using CNERs
SRX19713776	Whole genome enrichment of Mycobacteria using CNERs
SRX19713777	Whole genome enrichment of Mycobacteria using CNERs
SRX19713778	Whole genome enrichment of Mycobacteria using CNERs
SRX19713779	Whole genome enrichment of Mycobacteria using CNERs
SRX19713780	Whole genome enrichment of Mycobacteria using CNERs
SRX19713781	Whole genome enrichment of Mycobacteria using CNERs
SRX19713782	Whole genome enrichment of Mycobacteria using CNERs
SRX19713783	Whole genome enrichment of Mycobacteria using CNERs
SRX19713784	Whole genome enrichment of Mycobacteria using CNERs
SRX19713787	Whole genome enrichment of Mycobacteria using CNERs
SRX19713786	Whole genome enrichment of Mycobacteria using CNERs
SRX19713790	Shotgun sequencing of Mycobacteria
SRX19713785	Whole genome enrichment of Mycobacteria using CNERs
SRX19713789	Whole genome enrichment of Mycobacteria using CNERs
SRX19713791	Shotgun sequencing of Mycobacteria
SRX19713788	Whole genome sequencing of Mycobacteria
SRX19713793	Shotgun sequencing of Mycobacteria
SRX19713794	Whole genome enrichment of Mycobacteria using CNERs
SRX19713792	Shotgun sequencing of Mycobacteria
SRX19713796	Whole genome enrichment of Mycobacteria using CNERs
SRX19713797	Whole genome enrichment of Mycobacteria using CNERs
SRX19713795	Whole genome enrichment of Mycobacteria using CNERs
SRX19713799	Whole genome enrichment of Mycobacteria using CNERs
SRX19713798	Whole genome enrichment of Mycobacteria using CNERs
SRX19715929	Whole genome enrichment of Mycobacteria using CNERs
SRX19715931	Whole genome enrichment of Mycobacteria using CNERs
SRX19715928	Whole genome enrichment of Mycobacteria using CNERs
SRX19715933	Whole genome enrichment of Mycobacteria using CNERs
SRX19715927	Whole genome enrichment of Mycobacteria using CNERs
SRX19715937	Whole genome enrichment of Mycobacteria using CNERs
SRX19715934	Whole genome enrichment of Mycobacteria using CNERs
SRX19715939	Whole genome enrichment of Mycobacteria using CNERs
SRX19715936	Whole genome enrichment of Mycobacteria using CNERs
SRX19715941	Whole genome enrichment of Mycobacteria using CNERs
SRX19715932	Whole genome enrichment of Mycobacteria using CNERs
SRX19715940	Whole genome enrichment of Mycobacteria using CNERs
SRX19715942	Whole genome enrichment of Mycobacteria using CNERs
SRX19715945	Whole genome enrichment of Mycobacteria using CNERs
SRX19715938	Whole genome enrichment of Mycobacteria using CNERs
SRX19715947	Whole genome enrichment of Mycobacteria using CNERs
SRX19715944	Whole genome enrichment of Mycobacteria using CNERs
SRX19715946	Whole genome enrichment of Mycobacteria using CNERs
SRX19715943	Whole genome enrichment of Mycobacteria using CNERs
SRX19715951	Whole genome enrichment of Mycobacteria using CNERs
SRX19715949	Whole genome enrichment of Mycobacteria using CNERs
SRX19715953	Whole genome enrichment of Mycobacteria using CNERs
SRX19715950	Whole genome enrichment of Mycobacteria using CNERs
SRX19715948	Whole genome enrichment of Mycobacteria using CNERs
SRX19715954	Whole genome enrichment of Mycobacteria using CNERs
SRX19715957	Whole genome enrichment of Mycobacteria using CNERs
SRX19715955	Whole genome enrichment of Mycobacteria using CNERs
SRX19715959	Whole genome enrichment of Mycobacteria using CNERs
SRX19715952	Whole genome enrichment of Mycobacteria using CNERs
SRX19715961	Whole genome enrichment of Mycobacteria using CNERs
SRX19715958	Whole genome enrichment of Mycobacteria using CNERs
SRX19715963	Whole genome enrichment of Mycobacteria using CNERs
SRX19715960	Whole genome enrichment of Mycobacteria using CNERs
SRX19715965	Whole genome enrichment of Mycobacteria using CNERs
SRX19715956	Whole genome enrichment of Mycobacteria using CNERs
SRX19715967	Whole genome enrichment of Mycobacteria using CNERs
SRX19715935	Whole genome enrichment of Mycobacteria using CNERs
SRX19715930	Whole genome enrichment of Mycobacteria using CNERs
SRX19715964	Whole genome enrichment of Mycobacteria using CNERs
SRX19715969	Whole genome enrichment of Mycobacteria using CNERs
SRX19715966	Whole genome enrichment of Mycobacteria using CNERs
SRX19715971	Whole genome enrichment of Mycobacteria using CNERs
SRX19715962	Whole genome enrichment of Mycobacteria using CNERs
SRX19715970	Whole genome enrichment of Mycobacteria using CNERs
SRX19715972	Whole genome enrichment of Mycobacteria using CNERs
SRX19715975	Whole genome enrichment of Mycobacteria using CNERs
SRX19715968	Whole genome enrichment of Mycobacteria using CNERs
SRX19715977	Whole genome enrichment of Mycobacteria using CNERs
SRX19715974	Whole genome enrichment of Mycobacteria using CNERs
SRX19715979	Whole genome enrichment of Mycobacteria using CNERs
SRX19715976	Whole genome enrichment of Mycobacteria using CNERs
SRX19715981	Whole genome enrichment of Mycobacteria using CNERs
SRX19715973	Whole genome enrichment of Mycobacteria using CNERs
SRX19715978	Whole genome enrichment of Mycobacteria using CNERs
SRX19715980	Whole genome enrichment of Mycobacteria using CNERs
SRX19715982	Whole genome enrichment of Mycobacteria using CNERs
SRX19715983	Whole genome enrichment of Mycobacteria using CNERs
SRX19715984	Whole genome enrichment of Mycobacteria using CNERs
SRX19715985	Whole genome enrichment of Mycobacteria using CNERs
SRX19715986	Whole genome enrichment of Mycobacteria using CNERs
SRX19715987	Whole genome enrichment of Mycobacteria using CNERs
SRX19715988	Whole genome enrichment of Mycobacteria using CNERs
SRX19715989	Whole genome enrichment of Mycobacteria using CNERs
SRX19715990	Whole genome enrichment of Mycobacteria using CNERs
SRX19715991	Whole genome enrichment of Mycobacteria using CNERs
SRX19715992	Whole genome enrichment of Mycobacteria using CNERs
SRX19715993	Whole genome enrichment of Mycobacteria using CNERs
SRX19715994	Whole genome enrichment of Mycobacteria using CNERs
SRX19715995	Whole genome enrichment of Mycobacteria using CNERs
SRX19715996	Whole genome enrichment of Mycobacteria using CNERs
SRX19715997	Whole genome enrichment of Mycobacteria using CNERs
SRX19715999	Whole genome enrichment of Mycobacteria using CNERs
SRX19715998	Whole genome enrichment of Mycobacteria using CNERs
SRX19716001	Whole genome enrichment of Mycobacteria using CNERs
SRX19716000	Whole genome enrichment of Mycobacteria using CNERs
SRX19716005	Whole genome enrichment of Mycobacteria using CNERs
SRX19716002	Whole genome enrichment of Mycobacteria using CNERs
SRX19716007	Whole genome enrichment of Mycobacteria using CNERs
SRX19716004	Whole genome enrichment of Mycobacteria using CNERs
SRX19716009	Whole genome enrichment of Mycobacteria using CNERs
SRX19716006	Whole genome enrichment of Mycobacteria using CNERs
SRX19716011	Whole genome enrichment of Mycobacteria using CNERs
SRX19716008	Whole genome enrichment of Mycobacteria using CNERs
SRX19716003	Whole genome enrichment of Mycobacteria using CNERs
SRX19716010	Whole genome enrichment of Mycobacteria using CNERs
SRX19716012	Whole genome enrichment of Mycobacteria using CNERs
SRX19716017	Whole genome enrichment of Mycobacteria using CNERs
SRX19716014	Whole genome enrichment of Mycobacteria using CNERs
SRX19716019	Whole genome enrichment of Mycobacteria using CNERs
SRX19716016	Whole genome enrichment of Mycobacteria using CNERs
SRX19716018	Whole genome enrichment of Mycobacteria using CNERs
SRX19716015	Whole genome enrichment of Mycobacteria using CNERs
SRX19716013	Whole genome enrichment of Mycobacteria using CNERs
SRX19716020	Whole genome enrichment of Mycobacteria using CNERs
SRX19716022	Whole genome enrichment of Mycobacteria using CNERs
SRX19716021	Whole genome enrichment of Mycobacteria using CNERs
SRX19716023	Shotgun sequencing of Mycobacteria
SRX19716025	Whole genome enrichment of Mycobacteria using CNERs
SRX19716024	Shotgun sequencing of Mycobacteria
SRX19716026	Whole genome enrichment of Mycobacteria using CNERs
SRX19716029	Whole genome enrichment of Mycobacteria using CNERs
SRX19716031	Shotgun sequencing of Mycobacteria
SRX19716028	Whole genome enrichment of Mycobacteria using CNERs
SRX19716030	Whole genome enrichment of Mycobacteria using CNERs
SRX19716027	Whole genome enrichment of Mycobacteria using CNERs
SRX19716035	Shotgun sequencing of Mycobacteria
SRX19716033	Shotgun sequencing of Mycobacteria
SRX19716037	Shotgun sequencing of Mycobacteria
SRX19716034	Shotgun sequencing of Mycobacteria
SRX19716032	Shotgun sequencing of Mycobacteria
SRX19716038	Shotgun sequencing of Mycobacteria
SRX19716041	Shotgun sequencing of Mycobacteria
SRX19716039	Shotgun sequencing of Mycobacteria
SRX19716043	Shotgun sequencing of Mycobacteria
SRX19716036	Shotgun sequencing of Mycobacteria
SRX19716042	Shotgun sequencing of Mycobacteria
SRX19716044	Shotgun sequencing of Mycobacteria
SRX19716047	Shotgun sequencing of Mycobacteria
SRX19716040	Shotgun sequencing of Mycobacteria
SRX19716046	Shotgun sequencing of Mycobacteria
SRX19716048	Shotgun sequencing of Mycobacteria
SRX19716050	Shotgun sequencing of Mycobacteria
SRX19716053	Shotgun sequencing of Mycobacteria
SRX19716045	Shotgun sequencing of Mycobacteria
SRX19716055	Shotgun sequencing of Mycobacteria
SRX19716051	Shotgun sequencing of Mycobacteria
SRX19716057	Shotgun sequencing of Mycobacteria
SRX19716052	Shotgun sequencing of Mycobacteria
SRX19716059	Shotgun sequencing of Mycobacteria
SRX19716054	Shotgun sequencing of Mycobacteria
SRX19716056	Shotgun sequencing of Mycobacteria
SRX19716058	Shotgun sequencing of Mycobacteria
SRX19716060	Shotgun sequencing of Mycobacteria
SRX19716065	Shotgun sequencing of Mycobacteria
SRX19716062	Shotgun sequencing of Mycobacteria
SRX19716067	Shotgun sequencing of Mycobacteria
SRX19716064	Shotgun sequencing of Mycobacteria
SRX19716066	Shotgun sequencing of Mycobacteria
SRX19716068	Shotgun sequencing of Mycobacteria
SRX19716071	Shotgun sequencing of Mycobacteria
SRX19716063	Shotgun sequencing of Mycobacteria
SRX19716073	Shotgun sequencing of Mycobacteria
SRX19716069	Shotgun sequencing of Mycobacteria
SRX19716075	Shotgun sequencing of Mycobacteria
SRX19716070	Shotgun sequencing of Mycobacteria
SRX19716077	Shotgun sequencing of Mycobacteria
SRX19716072	Shotgun sequencing of Mycobacteria
SRX19716079	Shotgun sequencing of Mycobacteria
SRX19716074	Shotgun sequencing of Mycobacteria
SRX19716076	Shotgun sequencing of Mycobacteria
SRX19716078	Shotgun sequencing of Mycobacteria
SRX19716083	Shotgun sequencing of Mycobacteria
SRX19716080	Shotgun sequencing of Mycobacteria
SRX19716085	Shotgun sequencing of Mycobacteria
SRX19716082	Shotgun sequencing of Mycobacteria
SRX19716084	Shotgun sequencing of Mycobacteria
SRX19716086	Shotgun sequencing of Mycobacteria
SRX19716089	Shotgun sequencing of Mycobacteria
SRX19716081	Shotgun sequencing of Mycobacteria
SRX19716087	Shotgun sequencing of Mycobacteria
SRX19716088	Shotgun sequencing of Mycobacteria
SRX19716090	Shotgun sequencing of Mycobacteria
SRX19716095	Shotgun sequencing of Mycobacteria
SRX19716092	Shotgun sequencing of Mycobacteria
SRX19716097	Shotgun sequencing of Mycobacteria
SRX19716093	Shotgun sequencing of Mycobacteria
SRX19716094	Shotgun sequencing of Mycobacteria
SRX19716096	Shotgun sequencing of Mycobacteria
SRX19716101	Whole genome enrichment of Mycobacteria using CNERs
SRX19716102	Whole genome enrichment of Mycobacteria using CNERs
SRX19716091	Shotgun sequencing of Mycobacteria
SRX19716099	Shotgun sequencing of Mycobacteria
SRX19716100	Shotgun sequencing of Mycobacteria
SRX19716098	Shotgun sequencing of Mycobacteria
SRX19716061	Shotgun sequencing of Mycobacteria
SRX19716049	Shotgun sequencing of Mycobacteria