项目编号

PRJNA998802

项目标题

Single-cell transcriptomic analysis reveals that inflammation drives the unfolded protein response during endocrine aging in mice

涉及领域

ModelOrganism

数据类型

Transcriptome or Gene expression

样品范围

Multiisolate

生物名称

Mus musculus [Taxonomy ID: 10090]

描述信息

The endocrine system severely impacts individual aging. However, its cellular signatures and underlying mechanisms have not been comprehensively elucidated. Here, we present a comprehensive single-cell transcriptomic atlas of six endocrine tissues from young and aged mice. Multiple aging-related pathways are disrupted in endocrine tissues, and the unfolded protein response (UPR) emerged as a key pathway related to endocrine aging. We found significant age-related expansion of exhausted GZMK+CD8+ T cells within endocrine tissues. Additionally, granzyme K (GZMK) signaling enhances the UPR and accelerates cellular senescence through the modulation of MHC-I expression in functional endocrine cells, revealing a novel regulatory axis of aging. Moreover, the inhibition of the GZMK receptor counteracts the UPR and endocrine aging. These findings establish an interplay between inflammation and the UPR in endocrine aging, offering profound insights into the underlying mechanisms of endocrine aging. Overall design: We isolated the hypothalamus, pituitary glands, thyroid glands, adrenal glands, pancreas islets, and pineal glands from aged mice and young mice.

出版信息

PubMed ID	文章标题	杂志名称	Doi	发表年份
40899455

项目相关网站链接

网站信息描述

发布日期

2026-03-12

提交单位

Peking University

数据来源

NCBI

项目包含数据信息

资源名称	描述
Experiment (24) show	-
SRX21168590	GSM7663097: Hypothalamus, young, sample2, snRNA-seq; Mus musculus; RNA-Seq
SRX21168591	GSM7663096: Hypothalamus, aged, sample1, snRNA-seq; Mus musculus; RNA-Seq
SRX21168592	GSM7663098: Hypothalamus, aged, sample2, snRNA-seq; Mus musculus; RNA-Seq
SRX21168593	GSM7663099: Pituitary, young, sample1, scRNA-seq; Mus musculus; RNA-Seq
SRX21168594	GSM7663100: Pituitary, aged, sample1, scRNA-seq; Mus musculus; RNA-Seq
SRX21168595	GSM7663101: Pituitary, young, sample2, scRNA-seq; Mus musculus; RNA-Seq
SRX21168596	GSM7663102: Pituitary, aged, sample2, scRNA-seq; Mus musculus; RNA-Seq
SRX21168597	GSM7663111: Adrenal gland, young, sample1, scRNA-seq; Mus musculus; RNA-Seq
SRX21168598	GSM7663112: Adrenal gland, aged, sample1, scRNA-seq; Mus musculus; RNA-Seq
SRX21168599	GSM7663113: Adrenal gland, young, sample2, scRNA-seq; Mus musculus; RNA-Seq
SRX21168600	GSM7663114: Adrenal gland, aged, sample2, scRNA-seq; Mus musculus; RNA-Seq
SRX21168601	GSM7663115: Pancreas islet, young, sample1, scRNA-seq; Mus musculus; RNA-Seq
SRX21168602	GSM7663116: Pancreas islet, aged, sample1, scRNA-seq; Mus musculus; RNA-Seq
SRX21168603	GSM7663117: Pancreas islet, young, sample2, scRNA-seq; Mus musculus; RNA-Seq
SRX21168604	GSM7663095: Hypothalamus, young, sample1, snRNA-seq; Mus musculus; RNA-Seq
SRX21168605	GSM7663118: Pancreas islet, aged, sample2, scRNA-seq; Mus musculus; RNA-Seq
SRX21168606	GSM7663103: Pineal gland, young, sample1, scRNA-seq; Mus musculus; RNA-Seq
SRX21168607	GSM7663104: Pineal gland, aged, sample1, scRNA-seq; Mus musculus; RNA-Seq
SRX21168608	GSM7663105: Pineal gland, young, sample2, scRNA-seq; Mus musculus; RNA-Seq
SRX21168609	GSM7663106: Pineal gland, aged, sample2, scRNA-seq; Mus musculus; RNA-Seq
SRX21168610	GSM7663107: Thyroid gland, young, sample1, scRNA-seq; Mus musculus; RNA-Seq
SRX21168611	GSM7663108: Thyroid gland, aged, sample1, scRNA-seq; Mus musculus; RNA-Seq
SRX21168612	GSM7663110: Thyroid gland, aged, sample2, scRNA-seq; Mus musculus; RNA-Seq
SRX21168613	GSM7663109: Thyroid gland, young, sample2, scRNA-seq; Mus musculus; RNA-Seq