Accession SAMC1547654
Accession in Other Database GSA-Human: HRS121822
Sample name Dam-Emerin_SIRT3_KO_P4
Title Dam-Emerin_SIRT3_KO_P4
Sample type Human sample
Organism Homo sapiens
Description Dam-EMD of SIRT3 KO hMSCs at early passage in DamID-seq
Attributes
Isolate not collected
Age
Biomaterial provider IOZ
Sex female
Tissue mesenchymal stem cell
Disease
Cell line
Cell subtype
Cell type
Culture collection
Development stage
Disease stage
Ethnicity
Health State
Karyotype
Phenotype
Population
Race
Type
Treatment
Collection date 2019-10-27
Custom attributes
Release date 2020-12-15
BioProject Accession PRJCA003860
Submitter Guanghui  Liu  (ghliu@ioz.ac.cn)
Organization Institute of Zoology, Chinese Academy of Sciences
Submission date 2023-06-18

Sample Data

Resource name Description
GSA-Human (1) -
HRA000466  (Open Access) Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase involved in various physiological and pathological processes. However, the role of SIRT3 in regulating human stem cell senescence remains largely unknown. Our study reveals a novel role of nuclear SIRT3 in stabilizing heterochromatin and counteracting hMSC senescence, which may provide new clinical therapeutic targets to ameliorate aging-related diseases.