样本编号	SAMC2324058
外部数据库编号	GSA-Human: HRS445303
样品名称	132129S03
样本标题	tumor sample from D18
样品类型	Human sample
物种名称	Homo sapiens
描述信息	tumor
样本属性	*该样本包含更多受控访问信息，请通过GSA-Human系统申请项目HRA003043数据获取。
发布日期	2022-09-15
项目编号	PRJCA011820
提交者	Laiping Zhong (dongyu.liu@3dmedcare.com)
提交单位	Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine
提交日期	2023-06-18

样本包含数据信息

资源名称	描述
GSA-Human (1)	-
HRA003043 (Controlled Access)	20 locally advanced oral squamous cell carcinoma patients were enrolled. Neoadjuvant immunochemotherapy (NAICT) was well-tolerated with low incidence of grade 3-4 adverse events (AEs) in three patients (15%). Using pathological evaluation for NAICT, the major pathologic response (MPR) rate was 60% (12/20), including 30% (6/20) pCR. MPR was archived in all 4 patients with combined positive score of PD-L1>10. Using radiographical evaluation, there were 10% of CR and 50% of PR. The pathological and radiographical response was consistent in linear regression analysis (P<0.001). The pathological response pattern to NAICT was scatter pattern in 92.9% (13/14) of patients, with multiple residual foci. Patients with higher TMB and more immune activation cells in biopsies tended to show higher MPR rate, respectively. More tertiary lymphoid structure was found in the post-NAICT surgical specimens than pre-NAICT biopsies (P=0.03), especially in the MPR group (P=0.009).

资源名称

描述

GSA-Human (1)

HRA003043 (Controlled Access)

20 locally advanced oral squamous cell carcinoma patients were enrolled. Neoadjuvant immunochemotherapy (NAICT) was well-tolerated with low incidence of grade 3-4 adverse events (AEs) in three patients (15%). Using pathological evaluation for NAICT, the major pathologic response (MPR) rate was 60% (12/20), including 30% (6/20) pCR. MPR was archived in all 4 patients with combined positive score of PD-L1>10. Using radiographical evaluation, there were 10% of CR and 50% of PR. The pathological and radiographical response was consistent in linear regression analysis (P<0.001). The pathological response pattern to NAICT was scatter pattern in 92.9% (13/14) of patients, with multiple residual foci. Patients with higher TMB and more immune activation cells in biopsies tended to show higher MPR rate, respectively. More tertiary lymphoid structure was found in the post-NAICT surgical specimens than pre-NAICT biopsies (P=0.03), especially in the MPR group (P=0.009).