Accession

SAMC2361253

Accession in Other Database

Sample name

UC1_MSC

Title

UC1

Sample type

Human sample

Organism

Homo sapiens

Description

single cell trascriptome from MSCs of healthy donor

Attributes

Isolate	not collected
Age
Biomaterial provider	Institute of Hematology and Blood Diseases Hospital, Tianjin, China
Sex	male
Tissue	Umbilical cord
Disease
Cell line
Cell subtype
Cell type
Culture collection
Development stage
Disease stage
Ethnicity	Han Chinese
Health State
Karyotype
Phenotype
Population
Race
Type
Treatment
Collection date	2019-03-01

Custom attributes

Release date

2024-10-12

BioProject Accession

PRJCA012439

Submitter

Yuchen Gao (zhanglei1@ihcams.ac.cn)

Organization

Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences

Submission date

2023-06-18

Sample Data

Resource name	Description
GSA-Human (1)	-
HRA003248 (Open Access)	Here, we use single cell transcriptomics to characterize a dynamic senescence process of in vitro expanded MSC products from adipose tissue (AD), bone marrow (BM), placenta membrane (PM) and umbilical cord (UC). We found that cultured MSCs underwent progressive cell aging. As compared to perinatal MSCs (derived from PM and UC), adult MSCs (derived from AD and BM) showed higher degree of senescence and impaired immunosuppressive function. Moreover, we identified the transcriptional network regulating the intra-population functional diversity, which provides us guidance to drive reprogramming of determined MSCs lineage with specific cellular functions for a particular therapeutic intent.

Resource name

Description

GSA-Human (1)

HRA003248 (Open Access)

Here, we use single cell transcriptomics to characterize a dynamic senescence process of in vitro expanded MSC products from adipose tissue (AD), bone marrow (BM), placenta membrane (PM) and umbilical cord (UC). We found that cultured MSCs underwent progressive cell aging. As compared to perinatal MSCs (derived from PM and UC), adult MSCs (derived from AD and BM) showed higher degree of senescence and impaired immunosuppressive function. Moreover, we identified the transcriptional network regulating the intra-population functional diversity, which provides us guidance to drive reprogramming of determined MSCs lineage with specific cellular functions for a particular therapeutic intent.

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